Evidence map›Paper›PMID 38553325›Full record

ArticleClinical lung cancer2024

Lung Cancer Survival Trends in the Veterans Health Administration.

Drew Moghanaki, James Taylor, Alex K Bryant, Lucas K Vitzthum, Nikhil Sebastian, David Gutman, Abigail Burns, Zhonglu Huang, Jennifer A Lewis, Lucy B Spalluto and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Clinical lung cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 1 country.

Drew MoghanakiVeterans Affairs Greater Los Angeles Healthcare System, Radiation Oncology Service, Los Angeles, CA; University of California Los Angeles Jonsson Comprehensive Cancer Center, Los Angeles, CA. Electronic address: drew.moghanaki@va.gov.
James TaylorGenesisCare of North Carolina, Asheville, NC.
Alex K BryantDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI.
Lucas K VitzthumDepartment of Radiation Oncology, Stanford University, Palo Alto, CA; Office of Research and Development, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA.
Nikhil SebastianDepartment of Radiation Oncology, Emory University School of Medicine, Atlanta, GA; Winship Cancer Institute of Emory University, Atlanta, GA.
David GutmanDepartment of Psychiatry, Atlanta Veterans Affairs Health Care System, Decatur, GA; Department of Neurology, Emory University School of Medicine, Atlanta, GA.
Abigail BurnsFoundation for Atlanta Veterans Education and Research, Decatur, GA.
Zhonglu HuangWinship Cancer Institute of Emory University, Atlanta, GA.
Jennifer A LewisEducation and Clinical Center (GRECC) and Medicine Service, Veterans Health Administration-Tennessee Valley Healthcare System Geriatric Research, Nashville, TN; Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN; Vanderbilt-Ingram Cancer Center, Nashville, TN.
Lucy B SpallutoVanderbilt-Ingram Cancer Center, Nashville, TN; Education and Clinical Center (GRECC), Veterans Health Administration-Tennessee Valley Health Care System Geriatric Research, Nashville, TN; Department of Radiology, Vanderbilt University Medical Center, Nashville, TN.
Christina D WilliamsCooperative Studies Program Epidemiology Center, Durham VA Health Care System, Durham, NC; Department of Medicine, Duke University, Durham, NC; Duke Cancer Institute, Duke University, Durham, NC.
Donald R SullivanDivision of Pulmonary, Oregon Health and Science University, Allergy and Critical Care Medicine, Portland, OR; Center to Improve Veteran Involvement in Care, VA Portland Health Care System, Portland, OR; Cancer Prevention and Control Program, Oregon Health and Science University Knight Cancer Institute, Portland, OR.
Christopher G SlatoreDivision of Pulmonary, Oregon Health and Science University, Allergy and Critical Care Medicine, Portland, OR; Center to Improve Veteran Involvement in Care, VA Portland Health Care System, Portland, OR; Section of Pulmonary and Critical Care Medicine, VA Portland Health Care System, Portland, OR; Department of Radiation Medicine, Oregon Health and Science University Knight Cancer Institute, Portland, OR.
Madhusmita BeheraWinship Cancer Institute of Emory University, Atlanta, GA.
William A StokesDepartment of Radiation Oncology, Emory University School of Medicine, Atlanta, GA; Winship Cancer Institute of Emory University, Atlanta, GA.
Emory University · USOregon Health & Science University · USVanderbilt University · USAtlanta Research and Education Foundation · USDuke University · USUniversity of California, Los Angeles · USUniversity of Michigan · USUniversity of North Carolina at Asheville · USVA Palo Alto Health Care System · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Suresh S Ramalingam · 2009 to 2026
$47.5M
Project 3: Targeting Bax signaling to overcome treatment resistance in NSCLCP50CA217691 · NCI · EMORY UNIVERSITY · PI SICA, GABRIEL LARKIN · 2019 to 2024
$10.1M
Vanderbilt Scholars in T4 Translational Research (V-STTaR) ProgramK12HL137943 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KRIPALANI, SUNIL, ROUMIE, CHRISTIANNE L. · 2017 to 2021
$2.9M
NCI NIH HHS P30 CA068485NCI NIH HHS P30 CA138292NCI NIH HHS P50 CA217691NHLBI NIH HHS K12 HL137943
6 · The paper itself

Abstract

introductionLung cancer survival is improving in the United States. We investigated whether there was a similar trend within the Veterans Health Administration (VHA), the largest integrated healthcare system in the United States. MATERIALS AND

methodsData from the Veterans Affairs Central Cancer Registry were analyzed for temporal survival trends using Kaplan-Meier estimates and linear regression.

resultsA total number of 54,922 Veterans were identified with lung cancer diagnosed from 2010 to 2017. Histologies were classified as non-small-cell lung cancer (NSCLC) (64.2%), small cell lung cancer (SCLC) (12.9%), and 'other' (22.9%). The proportion with stage I increased from 18.1% to 30.4%, while stage IV decreased from 38.9% to 34.6% (both P < .001). The 3-year overall survival (OS) improved for stage I (58.6% to 68.4%, P < .001), stage II (35.5% to 48.4%, P < .001), stage III (18.7% to 29.4%, P < .001), and stage IV (3.4% to 7.8%, P < .001). For NSCLC, the median OS increased from 12 to 21 months (P < .001), and the 3-year OS increased from 24.1% to 38.3% (P < .001). For SCLC, the median OS remained unchanged (8 to 9 months, P = .10), while the 3-year OS increased from 9.1% to 12.3% (P = .014). Compared to White Veterans, Black Veterans with NSCLC had similar OS (P = .81), and those with SCLC had higher OS (P = .003).

conclusionLung cancer survival is improving within the VHA. Compared to White Veterans, Black Veterans had similar or higher survival rates. The observed racial equity in outcomes within a geographically and socioeconomically diverse population warrants further investigation to better understand and replicate this achievement in other healthcare systems.

Indexed as

Lung NeoplasmsUnited States Department of Veterans AffairsAgedAged, 80 and overCarcinoma, Non-Small-Cell LungFemaleHumansMaleMiddle AgedNeoplasm StagingRegistriesSmall Cell Lung CarcinomaSurvival RateUnited StatesVeteransVeterans HealthEpidemiologyHealth equityHeatlhcare disparitiesNon-small cell lung cancerRaceSmall-cell lung cancer

Identifiers

PMID38553325
PMCPMC11098707
OpenAlexW4392346603

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.