Evidence map›Paper›PMID 38553309›Full record

ArticleOral surgery, oral medicine, oral pathology and oral radiology2024

Recurrent central odontogenic fibroma in a patient with nevoid basal cell carcinoma syndrome: case report and in vitro analysis.

Dinesh K Yadav, Caris M Smith, Andrew B Zhang, Patricia DeVilliers, Stephen L Greene, Patrick J Louis, Mary MacDougall, Hope M Amm

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Oral surgery, oral medicine, oral pathology and oral radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Dinesh K YadavDepartment of Neurology, University of Alabama at Birmingham, School of Medicine, Birmingham, AL, USA.
Caris M SmithOral and Maxillofacial Surgery, University of Alabama at Birmingham, School of Dentistry, Birmingham, AL, USA.
Andrew B ZhangOral and Maxillofacial Surgery, University of Alabama at Birmingham, School of Dentistry, Birmingham, AL, USA.
Patricia DeVilliersDepartment of Pathology, University of Alabama at Birmingham, School of Medicine, Birmingham, AL, USA.
Stephen L GreeneOral and Maxillofacial Surgery, University of Alabama at Birmingham, School of Dentistry, Birmingham, AL, USA.
Patrick J LouisOral and Maxillofacial Surgery, University of Alabama at Birmingham, School of Dentistry, Birmingham, AL, USA.
Mary MacDougallOral and Maxillofacial Surgery, University of Alabama at Birmingham, School of Dentistry, Birmingham, AL, USA; Faculty of Dentistry, The University of British Columbia, Vancouver, BC, Canada.
Hope M AmmOral and Maxillofacial Surgery, University of Alabama at Birmingham, School of Dentistry, Birmingham, AL, USA. Electronic address: hopeamm@uab.edu.
University of Alabama at Birmingham · USUniversity of British Columbia · CA

Funding

Dental Academic Research Training Program (DART)T90DE022736 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Amjad Javed · 2012 to 2026
$6.7M
Hedgehog Pathway Activity and Targeting in KCOTR00DE023826 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMM, HOPE · 2017 to 2020
$813k
Hedgehog Pathway Activity and Targeting in KCOTK99DE023826 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMM, HOPE · 2015 to 2016
$247k
NIDCR NIH HHS K99 DE023826NIDCR NIH HHS R00 DE023826NIDCR NIH HHS T90 DE022736
6 · The paper itself

Abstract

objectiveCentral odontogenic fibromas (COF) are rare, benign tumors derived from dental mesenchymal tissue that may occur in the maxilla or mandible. This report describes primary and recurrent COF in the mandible of a patient with nevoid basal cell carcinoma syndrome (NBCCS). STUDY

designA 36-year-old African American male presented with a COF and its recurrence 17 months later. Tissue pieces were obtained from both occurrences with IRB-approved signed consent. Collected tissue pieces were dissected; one portion was formalin-fixed and paraffin-embedded, and the other was cultured for the isolation of cell populations from the primary (COdF-1) and recurrent (COdF-1a) tumors. Quantification real-time polymerase chain reaction (qRT-PCR), immunohistochemistry, and DNA sequencing were used for gene and protein analysis of the primary tumor and cell populations.

resultsHistopathologic analysis of the tumor showed sparse odontogenic epithelial cords in fibrous connective tissue, and qRT-PCR analysis of tumor and cell populations (COdF-1 and COdF-1a) detected VIM, CK14, CD34, CD99 and ALPL mRNA expression. Protein expression was confirmed by immunohistochemistry. CD34 expression in primary tissues was higher than in tumor cells due to tumor vascularization. DNA sequencing indicated the patient had PTCH1 mutations.

conclusionsHistopathology, mRNA, and protein expression indicate the rare occurrence of COF in a patient with mutated PTCH1 gene and NBCCS.

Indexed as

Basal Cell Nevus SyndromeFibromaNeoplasm Recurrence, LocalOdontogenic TumorsAdultHumansImmunohistochemistryIn Vitro TechniquesMaleMandibular NeoplasmsReal-Time Polymerase Chain Reaction

Identifiers

PMID38553309
PMCPMC11193645
OpenAlexW4392515254

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.