ArticleBrain, behavior, and immunity2024
Food insecurity, inflammation, and immune function among older US adults: Findings from the health and Retirement study.
Article in Brain, behavior, and immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Food insecurity in the development of metabolic diseases.Nature reviews. Endocrinology · 2026Review
- Neighborhood-Level Food Insecurity and Colorectal Cancer Incidence in Texas: A Spatial Ecological Analysis.Research square · 2026Article
- From pantry to physiology: A narrative review linking food insecurity to biological dysfunction.Dialogues in health · 2026Review
- Social determinants of health, behavioral factors, and incident dementia: a prospective cohort study.Alzheimer's research & therapy · 2026Article
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- Biosocial Factors Shaping Perceptions of Disease Risk Among a Community-Based Sample of Sexual and Gender Minority People Living in Toronto During the COVID-19 Pandemic.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Food Insecurity and Clinical Biomarkers of Inflammation among Cancer Survivors in the All of Us Research Program.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Food inflammation index reveals the key inflammatory components in foods and heterogeneity within food groups: How do we choose food?Journal of advanced research · 2025Article
- Food insecurity and cognitive domains among older United States adults: Findings from the health and retirement study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Area Deprivation and Clinical Biomarkers of Inflammation in Cancer Survivors of the National Institutes of Health All of Us Research Program.Cancer medicine · 2025Article
- Associations between low food security and subjective memory complaints among Latino adults.BMC public health · 2025Article
- Impact of food insecurity on cognitive health in older adults: insights from the NHANES 2011-2014 data.Frontiers in nutrition · 2024Article
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundFood insecurity (FI) is a pressing public health concern among older adults and has been associated with adverse cardiovascular outcomes. Greater systemic inflammation may provide a pathway to explain these associations, but few studies have examined the link between FI and markers of inflammation. Thus, the objective of the present study was to evaluate the associations between FI and multiple inflammatory and immune functioning biomarkers using a nationally representative study of US adults aged > 50 years.
methodParticipants (n = 3,924) were drawn from the longitudinal Health and Retirement Study (HRS). Household FI was assessed using the six-item Short Form Food Security Survey Module from the 2013 HRS Health Care and Nutrition Study. Markers of inflammation (neutrophil-lymphocyte ratio, albumin, hs-CRP, IL6, IL10, IL-1Ra, sTNFR-1, and TGFβ-1) and immune functioning (CMV) were collected during the 2016 HRS Venous Blood Study. Multivariate logistic and linear regression models were used to evaluate associations between household FI and inflammatory and immune functioning biomarkers, adjusting for individual and household sociodemographic characteristics.
resultsThe weighted prevalence of FI was 18.8 %. Age and sex-adjusted mean showed that FI was associated with higher levels of inflammation and impaired immune functioning (Ps-value < 0.05). Older adults with FI had higher mean levels of albumin, hs-CRP, IL6, IL10, IL-1Ra, TGFß-1, and CMV seronegative and borderline (Ps-value < 0.05). Multivariate-adjusted regression model showed that FI was associated with high-risk categories of hs-CRP (OR 1.34, 95 % CI 1.06, 1.68), IL-6 (OR 1.66, 95 % CI 1.28, 2.14), IL-1Ra (OR 0.67, 95 % CI 0.48, 0.93), TGFß-1 (OR 1.87, 95 % CI 1.45, 2.42), seronegativity for CMV (OR 0.48, 95 % CI 0.35, 0.64).
conclusionIn this nationally representative sample of older adults, FI was positively associated with multiple markers of systemic inflammation and impaired immune functioning. Public health efforts that directly work to reduce FI among older adults are warranted and may result in further improvements in their health and well-being.
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