Evidence map›Paper›PMID 38552897›Full record

ArticleAnaerobe2024

The impact of existing total anti-toxin B IgG immunity in outcomes of recurrent Clostridioides difficile infection.

Isaura Rigo, Mary K Young, Mayuresh M Abhyankar, Feifan Xu, Girija Ramakrishnan, Farha Naz, Gregory R Madden, William A Petri

Open access · greenAbstract read
In one paragraph

Article in Anaerobe, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Clostridioides difficile pathogenesis and control.Nature reviews. Microbiology · 2026
    Review
  3. Review
  4. Article
  5. IL-33 protects from recurrentbioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Isaura RigoUniversity of Virginia, Department of Medicine/ Infectious Disease and International Health, USA.
Mary K YoungUniversity of Virginia, Department of Medicine/ Infectious Disease and International Health, USA.
Mayuresh M AbhyankarUniversity of Virginia, Department of Medicine/ Infectious Disease and International Health, USA.
Feifan XuUniversity of Virginia, Department of Medicine/ Infectious Disease and International Health, USA.
Girija RamakrishnanUniversity of Virginia, Department of Medicine/ Infectious Disease and International Health, USA.
Farha NazUniversity of Virginia, Department of Medicine/ Infectious Disease and International Health, USA.
Gregory R MaddenUniversity of Virginia, Department of Medicine/ Infectious Disease and International Health, USA.
William A PetriUniversity of Virginia, Department of Medicine/ Infectious Disease and International Health, USA. Electronic address: wap3g@virginia.edu.
University of Virginia · US

Funding

INFECTIOUS DISEASES TRAINING PROGRAMT32AI007046 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Alison K Criss, William A Petri · 1985 to 2026
$15.3M
Role of Th17 in Severe and Recurrent C. difficile InfectionR01AI152477 · NIAID · UNIVERSITY OF VIRGINIA · PI PETRI, WILLIAM A, RAMAKRISHNAN, GIRIJA · 2020 to 2025
$7.1M
Role of Type 2 Immunity in Innate Protection from C. difficileR01AI124214 · NIAID · UNIVERSITY OF VIRGINIA · PI William A Petri · 2016 to 2026
$5.4M
Immune profiling to stratify Clostridioides difficile infection outcomesK23AI163368 · NIAID · UNIVERSITY OF VIRGINIA · PI MADDEN, GREGORY RUSSELL · 2021 to 2025
$961k
NIAID NIH HHS K23 AI163368NIAID NIH HHS R01 AI124214NIAID NIH HHS R01 AI152477NIAID NIH HHS T32 AI007046
6 · The paper itself

Abstract

Late anti-toxin-B humoral immunity acquired after treatment is important for preventing recurrent Clostridioides difficile infection. We prospectively-measured anti-toxin-B IgG and neutralization titers at diagnosis as potential early predictors of recurrence. High anti-toxin-B-IgG/neutralizing antibodies were associated with short-lasting protection within 6-weeks, however, no difference in recurrence risk was observed by 90-days post-infection.

Indexed as

Antibodies, BacterialBacterial ToxinsClostridioides difficileClostridium InfectionsImmunoglobulin GRecurrenceAdultAgedAged, 80 and overAntibodies, NeutralizingBacterial ProteinsFemaleHumansMaleMiddle AgedProspective StudiesAntibodies, BacterialAntibodies, NeutralizingBacterial ProteinsBacterial ToxinsImmunoglobulin GtoxB protein, Clostridium difficileanti-toxin B IgG antibodiesC. difficile infection (CDI)Neutralizing antibodies

Identifiers

PMID38552897
PMCPMC11180572
OpenAlexW4393254922

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.