Evidence map›Paper›PMID 38552670›Full record

ArticleGastroenterology2024

Comparative Effectiveness and Cost-Effectiveness of Colorectal Cancer Screening With Blood-Based Biomarkers (Liquid Biopsy) vs Fecal Tests or Colonoscopy.

Uri Ladabaum, Ajitha Mannalithara, Yingjie Weng, Robert E Schoen, Jason A Dominitz, Manisha Desai, David Lieberman

Registry-linked trialAbstract readComparative Study
In one paragraph

Article in Gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06929481 (Screening With Liquid Biopsies to Address Colorectal Cancer Inequities), which is not on this map. Cited by 59 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06929481 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Screening With Liquid Biopsies to Address Colorectal Cancer Inequities

TypeinterventionalSponsorUniversity of California, San DiegoRan2025 to 2026Enrolled340ConditionsColorectal Cancer Screening, Colorectal Cancer (CRC)ArmsCell free DNA (cfDNA) blood test, At home Fecal Immunochemical Test (FIT) or Colonoscopy
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. [Prevention and early detection of colorectal cancer].Innere Medizin (Heidelberg, Germany) · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Diagnostic performance of LINE-1 repetitive elements in stool DNA for non-invasive detection of colorectal cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Novel Liquid Biopsy in Gastrointestinal Cancers.Journal of gastroenterology and hepatology · 2026
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Uri LadabaumDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California; Department of Medicine, Stanford University School of Medicine, Stanford, California. Electronic address: uri.ladabaum@stanford.edu.
Ajitha MannalitharaDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California; Department of Medicine, Stanford University School of Medicine, Stanford, California.
Yingjie WengDepartment of Medicine, Stanford University School of Medicine, Stanford, California; Quantitative Sciences Unit, Stanford University School of Medicine, Stanford, California.
Robert E SchoenDivision of Gastroenterology, Hepatology and Nutrition, Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Jason A DominitzVeterans Administration Puget Sound Health Care System, Seattle, Washington; Division of Gastroenterology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington.
Manisha DesaiDepartment of Medicine, Stanford University School of Medicine, Stanford, California; Quantitative Sciences Unit, Stanford University School of Medicine, Stanford, California.
David LiebermanDivision of Gastroenterology and Hepatology, Oregon Health and Sciences University, Portland, Oregon.

Funding

Blood-Based Testing for Advanced AdenomaU01CA271884 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROBERT E. SCHOEN, Cristian Tomasetti · 2022 to 2026
$4.6M
NCI NIH HHS U01 CA271884
6 · The paper itself

Abstract

BACKGROUND &

aimsColorectal cancer (CRC) screening is highly effective but underused. Blood-based biomarkers (liquid biopsy) could improve screening participation.

methodsUsing our established Markov model, screening every 3 years with a blood-based test that meets minimum Centers for Medicare & Medicaid Services' thresholds (CMS

resultsCMS

conclusionsCMS

Indexed as

ColonoscopyColorectal NeoplasmsCost-Benefit AnalysisEarly Detection of CancerOccult BloodAgedBiomarkers, TumorComparative Effectiveness ResearchFecesFemaleHealth Care CostsHumansIncidenceLiquid BiopsyMaleMarkov ChainsBiomarkers, TumorBlood-Based BiomarkerBlood-Based TestingColorectal CancerComparative EffectivenessCost-EffectivenessDecision AnalysisHealth EconomicsLiquid BiopsyScreening

Identifiers

PMID38552670
PMCPMC12279009

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.