Evidence map›Paper›PMID 38551935›Full record

ArticlePloS one2024

Fine-tuning TrailMap: The utility of transfer learning to improve the performance of deep learning in axon segmentation of light-sheet microscopy images.

Marjolein Oostrom, Michael A Muniak, Rogene M Eichler West, Sarah Akers, Paritosh Pande, Moses Obiri, Wei Wang, Kasey Bowyer, Zhuhao Wu, Lisa M Bramer and 2 more

Abstract read
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Adrenergic C1 neurons enhance anxiety via projections to PAG.bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Marjolein OostromAI & Data Analytics Division, Pacific Northwest National Laboratory, Richland, WA, United States of America.ORCID 0000-0002-1296-9084
Michael A MuniakVollum Institute, Oregon Health & Science University, Portland, OR, United States of America.ORCID 0000-0001-8047-5871
Rogene M Eichler WestAI & Data Analytics Division, Pacific Northwest National Laboratory, Richland, WA, United States of America.
Sarah AkersAI & Data Analytics Division, Pacific Northwest National Laboratory, Richland, WA, United States of America.
Paritosh PandeBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, United States of America.
Moses ObiriAI & Data Analytics Division, Pacific Northwest National Laboratory, Richland, WA, United States of America.
Wei WangAppel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, United States of America.
Kasey BowyerAppel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, United States of America.
Zhuhao WuAppel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, United States of America.
Lisa M BramerBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, United States of America.ORCID 0000-0002-8384-1926
Tianyi MaoVollum Institute, Oregon Health & Science University, Portland, OR, United States of America.
Bobbie Jo M Webb-RobertsonBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, United States of America.ORCID 0000-0002-4744-2397

Funding

Cell type atlasing of whole human brains using HOLiS: an optimized pipeline for staining, clearing, imaging, and analysisRF1MH128969 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HILLMAN, ELIZABETH M. C., OSTEN, PAVEL · 2021 to 2021
$9.1M
Multiplex imaging of neuronal activity and signaling dynamics underlying learning in discrete amygdala circuits of behaving mice.R01NS104944 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI LI, BO, MAO, TIANYI · 2018 to 2022
$5.0M
Genetic and physiological dissection of the circuit mechanisms in the striatum.R01NS081071 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI MAO, TIANYI · 2013 to 2023
$3.6M
Cell-Specific Visualization of Endogenous ProteinsRF1MH120119 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI MAO, TIANYI, ZHONG, HAINING · 2019 to 2019
$2.8M
NIMH NIH HHS RF1 MH120119NIMH NIH HHS RF1 MH128969NINDS NIH HHS R01 NS081071NINDS NIH HHS R01 NS104944
6 · The paper itself

Abstract

Light-sheet microscopy has made possible the 3D imaging of both fixed and live biological tissue, with samples as large as the entire mouse brain. However, segmentation and quantification of that data remains a time-consuming manual undertaking. Machine learning methods promise the possibility of automating this process. This study seeks to advance the performance of prior models through optimizing transfer learning. We fine-tuned the existing TrailMap model using expert-labeled data from noradrenergic axonal structures in the mouse brain. By changing the cross-entropy weights and using augmentation, we demonstrate a generally improved adjusted F1-score over using the originally trained TrailMap model within our test datasets.

Indexed as

Deep LearningAnimalsAxonsBrainMachine LearningMiceMicroscopy

Identifiers

PMID38551935
PMCPMC10980229

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.