Evidence map›Paper›PMID 38551740›Full record

ArticleJournal of neurology2024

Atypical Alzheimer's disease: new insights into an overlapping spectrum between the language and visual variants.

Neha Atulkumar Singh, Jonathan Graff-Radford, Mary M Machulda, Arenn F Carlos, Christopher G Schwarz, Matthew L Senjem, Clifford R Jack, Val J Lowe, Keith A Josephs, Jennifer L Whitwell

Open access · greenAbstract read
In one paragraph

Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Neha Atulkumar SinghDepartment of Neurology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.
Jonathan Graff-RadfordDepartment of Neurology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.
Mary M MachuldaDepartment of Psychiatry & Psychology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.
Arenn F CarlosDepartment of Neurology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.
Christopher G SchwarzDepartment of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.
Matthew L SenjemDepartment of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.
Clifford R JackDepartment of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.
Val J LoweDepartment of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.
Keith A JosephsDepartment of Neurology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.
Jennifer L WhitwellDepartment of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA. whitwell.jennifer@mayo.edu.ORCID http://orcid.org/0000-0001-6914-1563
Mayo Clinic · US

Funding

Molecular and structural imaging in atypical Alzheimer's disease: a longitudinal studyR01AG050603 · NIA · MAYO CLINIC ROCHESTER · PI WHITWELL, JENNIFER LOUISE · 2016 to 2025
$5.9M
PIB PET Scanning in Speech and Language Based DementiasR01DC010367 · NIDCD · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A · 2010 to 2014
$1.7M
Alzheimer's Association NIRG-12-242215National Institute of Health R01-AG50603NIA NIH HHS R01 AG050603NIDCD NIH HHS R01 DC010367NIH HHS R01-DC010367
6 · The paper itself

Abstract

Overlap between language and visual variants of atypical Alzheimer's disease (AD) has been reported. However, the extent, frequency of overlap, and its neuroanatomical underpinnings remain unclear. Eighty-two biomarker-confirmed AD patients who presented with either predominant language (n = 34) or visuospatial/perceptual (n = 48) deficits underwent detailed clinical examinations, MRI, and [

Indexed as

Alzheimer DiseaseLanguage DisordersMagnetic Resonance ImagingPositron-Emission TomographyAgedAged, 80 and overBrainFemaleHumansMaleMiddle Agedtau ProteinsVision Disorderstau ProteinsAtypical Alzheimer’s diseaseLogopenic progressive aphasiaMRIPosterior cortical atrophyTau PET

Identifiers

PMID38551740
PMCPMC11273322
OpenAlexW4393313713

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.