Evidence map›Paper›PMID 38551482›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2024

Chronic nicotine exposure is associated with electrophysiological and sympathetic remodeling in the intact rabbit heart.

Amanda Guevara, Charlotte E R Smith, Jessica L Caldwell, Lena Ngo, Lilian R Mott, I-Ju Lee, Srinivas Tapa, Zhen Wang, Lianguo Wang, William R Woodward and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Influence of e-cigarettes and their constituents on cardiac rhythm and arrhythmias.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  2. Insights into the effect of pre- and postnatal nicotine exposure on cardiovascular development and function.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Amanda GuevaraDepartment of Pharmacology, University of California Davis, Davis, California, United States.ORCID 0000-0001-6146-3736
Charlotte E R SmithDepartment of Pharmacology, University of California Davis, Davis, California, United States.ORCID 0000-0002-1165-1752
Jessica L CaldwellDepartment of Pharmacology, University of California Davis, Davis, California, United States.ORCID 0000-0002-8616-318X
Lena NgoDepartment of Pharmacology, University of California Davis, Davis, California, United States.
Lilian R MottDepartment of Pharmacology, University of California Davis, Davis, California, United States.ORCID 0000-0003-3144-8820
I-Ju LeeDepartment of Pharmacology, University of California Davis, Davis, California, United States.
Srinivas TapaDepartment of Pharmacology, University of California Davis, Davis, California, United States.ORCID 0000-0002-0223-3209
Zhen WangDepartment of Pharmacology, University of California Davis, Davis, California, United States.
Lianguo WangDepartment of Pharmacology, University of California Davis, Davis, California, United States.ORCID 0000-0002-4747-0419
William R WoodwardDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, United States.
G Andre NgDepartment of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.ORCID 0000-0001-5965-0671
Beth A HabeckerDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, United States.ORCID 0000-0002-4658-8730
Crystal M RipplingerDepartment of Pharmacology, University of California Davis, Davis, California, United States.ORCID 0000-0002-9908-4106
University of California, Davis · USOregon Health & Science University · USShantou University · CNUC Davis Health · USUniversity of Leicester · GB

Funding

Neurotrophins and post-infarct plasticity in cardiac sympathetic neuronsR01HL093056 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI BETH A HABECKER · 2009 to 2026
$7.9M
The Role of Adrenergic Stimulation in ArrhythmogenesisR01HL111600 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Crystal May Ripplinger · 2012 to 2026
$7.1M
Training Program in PharmacologyT32GM144303 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Donald M Bers, JOHANNES W HELL · 2022 to 2026
$2.1M
Sex differences in cardiac autonomic remodeling after myocardial infarctionR01HL170626 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Crystal May Ripplinger, Marmar Vaseghi · 2024 to 2026
$2.1M
Sex-dependent cardiac cyclic-AMP signaling and arrhythmias in the failing heartK99HL171836 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CALDWELL, JESSICA · 2024 to 2025
$216k
NHLBI NIH HHS R01 HL093056NHLBI NIH HHS R01 HL111600NIGMS NIH HHS T32 GM144303
6 · The paper itself

Abstract

Nicotine is the primary addictive component of tobacco products. Through its actions on the heart and autonomic nervous system, nicotine exposure is associated with electrophysiological changes and increased arrhythmia susceptibility. To assess the underlying mechanisms, we treated rabbits with transdermal nicotine (NIC, 21 mg/day) or control (CT) patches for 28 days before performing dual optical mapping of transmembrane potential (RH237) and intracellular Ca

Indexed as

Action PotentialsHeartHeart RateNicotineSympathetic Nervous SystemAdministration, CutaneousAnimalsArrhythmias, CardiacCalcium SignalingIsolated Heart PreparationMaleNicotinic AgonistsNorepinephrineRabbitsTransdermal PatchNicotineNicotinic AgonistsNorepinephrineaction potentialarrhythmiacalciumnicotinesympathetic

Identifiers

PMID38551482
PMCPMC11381014
OpenAlexW4393307686

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.