Evidence map›Paper›PMID 38551385›Full record

ReviewHepatology communications2024

Genetics of liver disease in adults.

Chigoziri Konkwo, Shanin Chowdhury, Silvia Vilarinho

Open access · goldAbstract readReview
In one paragraph

Review in Hepatology communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Genetic testing in liver diseases: Clinical applications.JHEP reports : innovation in hepatology · 2026
    Review
  2. Article
  3. Review
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  6. Review
  7. Article
  8. Review
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  10. Liver diseases: epidemiology, causes, trends and predictions.Signal transduction and targeted therapy · 2025
    Review
  11. [Reappraisal on the clinical diagnosis and treatment of hereditary liver diseases].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Chigoziri KonkwoDepartment of Internal Medicine, Section of Digestive Diseases, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0001-9082-7498
Shanin ChowdhuryDepartment of Internal Medicine, Section of Digestive Diseases, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0003-3011-3981
Silvia VilarinhoDepartment of Internal Medicine, Section of Digestive Diseases, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-2099-4212
Yale University · US

Funding

Medical Scientist Training ProgramT32GM136651 · NIGMS · YALE UNIVERSITY · PI BARBARA I KAZMIERCZAK · 2020 to 2026
$16.5M
Liver Pathobiology: insights through the lens of rare diseasesR01DK131033 · NIDDK · YALE UNIVERSITY · PI Silvia Vilarinho · 2022 to 2026
$2.4M
NIDDK NIH HHS R01 DK131033NIGMS NIH HHS T32 GM136651
6 · The paper itself

Abstract

Chronic liver disease stands as a significant global health problem with an estimated 2 million annual deaths across the globe. Combining the use of next-generation sequencing technologies with evolving knowledge in the interpretation of genetic variation across the human genome is propelling our understanding, diagnosis, and management of both rare and common liver diseases. Here, we review the contribution of risk and protective alleles to common forms of liver disease, the rising number of monogenic diseases affecting the liver, and the role of somatic genetic variants in the onset and progression of oncological and non-oncological liver diseases. The incorporation of genomic information in the diagnosis and management of patients with liver disease is driving the beginning of a new era of genomics-informed clinical hepatology practice, facilitating personalized medicine, and improving patient care.

Indexed as

Liver DiseasesAdultGenomicsHigh-Throughput Nucleotide SequencingHumansPrecision Medicine

Identifiers

PMID38551385
PMCPMC10984672
OpenAlexW4393305609

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.