Evidence map›Paper›PMID 38551313›Full record

ArticleInternational health2025

Uptake and challenges with daily oral pre-exposure prophylaxis among men who have sex with men and transgender women, suburban Yangon, Myanmar.

Ni Ni Tun, Frank Smithuis, Nyan Lynn Tun, Myo Min Min Hteik, Myat Ko Ko, Lutgarde Lynen, Tom Decroo, Eric Florence, Tinne Gils

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Ni Ni TunMedical Action Myanmar, Yangon, Myanmar.ORCID 0000-0003-1496-7813
Frank SmithuisMedical Action Myanmar, Yangon, Myanmar.
Nyan Lynn TunMyanmar Oxford Clinical Research Unit, Yangon, Myanmar.
Myo Min Min HteikMyanmar Oxford Clinical Research Unit, Yangon, Myanmar.
Myat Ko KoMedical Action Myanmar, Yangon, Myanmar.
Lutgarde LynenClinical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium.
Tom DecrooClinical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium.ORCID 0000-0002-1205-1484
Eric FlorenceDepartment of General Internal Medicine, Infectious and Tropical Diseases, University Hospital of Antwerp, Edegem, Belgium.
Tinne GilsClinical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium.ORCID 0000-0002-5518-9600
Myanmar Oxford Clinical Research Unit · MMUniversity of Antwerp · BEInstituut voor Tropische Geneeskunde · BEAntwerp University Hospital · BE

Funding

Global Fund to Fight AIDS, Tuberculosis and Malaria 20864-005-01Mercury Phoenix Trust FoundationUSAID 72048221CA00003
6 · The paper itself

Abstract

backgroundPre-exposure prophylaxis (PrEP) is effective for human immunodeficiency virus (HIV) prevention in risk groups. We assessed PrEP uptake and 12-month retention among men who have sex with men (MSM) and transgender women (TGW) in Myanmar during the coronavirus disease 2019 pandemic and a political crisis.

methodsUsing prospectively collected data, we assessed the proportion of persons eligible, initiated and retained 12 months on PrEP. We calculated HIV and syphilis incidence among those initiated on PrEP. Predictors of compliance to scheduled visits were assessed with fractional logistic regression.

resultsAmong 652 persons screened between July and December 2020, 85.3% were eligible and 38.8% initiated PrEP. The daily pill burden was the main reason (86.5%) for refusing PrEP. A history of HIV post-exposure prophylaxis (PEP) and having an HIV-positive partner not on anti-retroviral therapy (ART) was associated with PrEP uptake (p<0.05). The 12-month retention among those initiating PrEP was 43.0%. Age ≥25 y, a history of PEP and having an HIV-positive partner not on ART predicted better compliance with scheduled visits (p<0.05). HIV incidence among PrEP initiators was 3.1 per 100 person-years (95% confidence interval [CI] 1.3 to 7.4) and syphilis incidence was 17.6 per 100 person-years (95% CI 12.3 to 25.1).

conclusionsA PrEP program for MSM and TGW in Myanmar was implemented successfully under difficult circumstances. Alternative strategies are needed addressing PrEP uptake and retention.

Indexed as

HIV InfectionsHomosexuality, MalePre-Exposure ProphylaxisTransgender PersonsAdultAnti-HIV AgentsCOVID-19FemaleHumansIncidenceMaleMedication AdherenceMiddle AgedMyanmarProspective StudiesSARS-CoV-2Anti-HIV Agentsdaily oral PrEPHIV incidenceHIV preventionmen who have sex with menpre-exposure prophylaxistransgender women

Identifiers

PMID38551313
PMCPMC11697093
OpenAlexW4393318215

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.