Evidence map›Paper›PMID 38551058›Full record

ReviewCurrent protein & peptide science2024

Phase Separation of Chromatin Structure-related Biomolecules: A Driving Force for Epigenetic Regulations.

Jiao Wang, Yuchen Chen, Zixuan Xiao, Xikai Liu, Chengyu Liu, Kun Huang, Hong Chen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current protein & peptide science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jiao WangWuhan No.1 Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.
Yuchen ChenTongji School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Zixuan XiaoISA Wenhua Wuhan High School, Fenglin Road, Junshan New Town, Wuhan Economics & Technological Development Zone, Wuhan, Hubei 430119, China.
Xikai LiuHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Chengyu LiuWuhan No.1 Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.
Kun HuangTongji School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Hong ChenTongji School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Huazhong University of Science and Technology · CNWuhan University · CNWuhan No.1 Hospital · CNWuhan Science and Technology Bureau · CN

Funding

China Postdoctoral Science Foundation 2021M700050National Key R&D Program of China 2022YFA0806100Natural Science Foundation of China 32371171Natural Science Foundation of Hubei Province 2021CFA004, 2021CFB250Wuhan Science and Technology Bureau Innovation Project 2023020201020529
6 · The paper itself

Abstract

Intracellularly, membrane-less organelles are formed by spontaneous fusion and fission of macro-molecules in a process called phase separation, which plays an essential role in cellular activities. In certain disease states, such as cancers and neurodegenerative diseases, aberrant phase separations take place and participate in disease progression. Chromatin structure-related proteins, based on their characteristics and upon external stimuli, phase separate to exert functions like genome assembly, transcription regulation, and signal transduction. Moreover, many chromatin structure-related proteins, such as histones, histone-modifying enzymes, DNA-modifying enzymes, and DNA methylation binding proteins, are involved in epigenetic regulations through phase separation. This review introduces phase separation and how phase separation affects epigenetics with a focus on chromatin structure-related molecules.

Indexed as

ChromatinDNA MethylationEpigenesis, GeneticHistonesAnimalsChromatin Assembly and DisassemblyDNA-Binding ProteinsHumansPhase SeparationChromatinDNA-Binding ProteinsHistoneschromatinchromatin structure-related biomoleculesDNAepigenetics.histoneMembrane-less organellesphase separation

Identifiers

PMID38551058
OpenAlexW4393312738

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.