Evidence map›Paper›PMID 38550985›Full record

ArticleiScience2024

Creatine and low-dose lithium supplementation separately alter energy expenditure, body mass, and adipose metabolism for the promotion of thermogenesis.

M S Finch, G L Gardner, J L Braun, M S Geromella, J Murphy, K Colonna, R Dhaliwal, A Retta, A Mohammad, J A Stuart and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

M S FinchDepartment of Health Sciences, Brock University, St. Catharines, ON, Canada.
G L GardnerDepartment of Biological Sciences, Brock University, St. Catharines, ON, Canada.
J L BraunDepartment of Kinesiology, Brock University, St. Catharines, ON, Canada.
M S GeromellaDepartment of Kinesiology, Brock University, St. Catharines, ON, Canada.
J MurphyDepartment of Kinesiology, Brock University, St. Catharines, ON, Canada.
K ColonnaDepartment of Kinesiology, Brock University, St. Catharines, ON, Canada.
R DhaliwalDepartment of Health Sciences, Brock University, St. Catharines, ON, Canada.
A RettaDepartment of Health Sciences, Brock University, St. Catharines, ON, Canada.
A MohammadDepartment of Health Sciences, Brock University, St. Catharines, ON, Canada.
J A StuartDepartment of Biological Sciences, Brock University, St. Catharines, ON, Canada.
P J LeBlancDepartment of Health Sciences, Brock University, St. Catharines, ON, Canada.
V A FajardoDepartment of Kinesiology, Brock University, St. Catharines, ON, Canada.
B D RoyDepartment of Kinesiology, Brock University, St. Catharines, ON, Canada.
R E K MacPhersonDepartment of Health Sciences, Brock University, St. Catharines, ON, Canada.
Brock University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nutraceutical approaches to promote adipose tissue thermogenesis may help to prevent obesity onset. Creatine is a critical regulator of adipose metabolic function and low-dose lithium supplementation has been shown to promote adipose thermogenesis. In the present study, we sought to directly compare the two supplements for their effects on adipose metabolism and thermogenesis. We show that both supplements increase daily energy expenditure (EE) and reduce body mass in male Sprague-Dawley rats. Lithium increased brown adipose tissue (BAT) mitochondrial and lipolytic proteins that are associated with thermogenesis, while creatine increased BAT UCP1 and mitochondrial respiration. The BAT thermogenic findings were not observed in females. White adipose tissue and skeletal muscle markers of thermogenesis were unaltered with the supplements. Together, the data show that low-dose lithium and creatine have diverging effects on markers of BAT thermogenesis and that each increase daily EE and lower body mass in a sex-dependent manner.

Indexed as

Cell biologyObesity medicinePhysiology

Identifiers

PMID38550985
PMCPMC10973579
OpenAlexW4392641850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.