Evidence map›Paper›PMID 38550855›Full record

ArticleFrontiers in microbiology2024

Mice, myeloid cells, and dengue: a new model for unraveling vascular leakage mysteries.

Takeshi Kurosu, Yusuke Sakai, Yasusi Ami, Masayuki Shimojima, Tomoki Yoshikawa, Shuetsu Fukushi, Noriyo Nagata, Tadaki Suzuki, Hideki Ebihara, Masayuki Saijo

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Takeshi KurosuDepartment of Virology I, National Institute of Infectious Diseases, Tokyo, Japan.
Yusuke SakaiDepartment of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
Yasusi AmiManagement Department of Biosafety, Laboratory Animal, and Pathogen Bank, National Institute of Infectious Diseases, Tokyo, Japan.
Masayuki ShimojimaDepartment of Virology I, National Institute of Infectious Diseases, Tokyo, Japan.
Tomoki YoshikawaDepartment of Virology I, National Institute of Infectious Diseases, Tokyo, Japan.
Shuetsu FukushiDepartment of Virology I, National Institute of Infectious Diseases, Tokyo, Japan.
Noriyo NagataDepartment of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
Tadaki SuzukiDepartment of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
Hideki EbiharaDepartment of Virology I, National Institute of Infectious Diseases, Tokyo, Japan.
Masayuki SaijoDepartment of Virology I, National Institute of Infectious Diseases, Tokyo, Japan.
National Institute of Infectious Diseases · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Severe dengue is thought to be caused by an excessive host immune response. Methods: To study the pathogenesis of severe dengue, we developed a novel model using LysM Cre Results: Although dengue virus (DENV) clinical isolates were not virulent in LysM Cre Discussion: These observations suggest that myeloid cell infection is sufficient to trigger cytokine storm-induced vascular leakage. This model can refine the factors involved in the pathology of severe dengue leading to vascular leakage.

Indexed as

bone marrow suppressioncytokine stormmyeloid cellspathogenic mechanismssevere denguevascular leakageviral adaptation

Identifiers

PMID38550855
PMCPMC10972876
OpenAlexW4392814888

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.