Evidence map›Paper›PMID 38550701›Full record

ArticleChemical science2024

Rational design of a cyclohexanone dehydrogenase for enhanced α,β-desaturation and substrate specificity.

Warispreet Singh, Nicola L Brown, Hannah V McCue, Sophie R Marriott, Richard C Wilson, Justin Perry, Johan P Turkenburg, Kshatresh D Dubey, Stephen H Prior, Andrew J Carnell and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Special Issue: "Rational Design and Synthesis of Bioactive Molecules".International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Warispreet SinghHub for Biotechnology in Build Environment, Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University Newcastle upon Tyne NE1 8ST UK gary.black@northumbria.ac.uk.
Nicola L BrownHub for Biotechnology in Build Environment, Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University Newcastle upon Tyne NE1 8ST UK gary.black@northumbria.ac.uk.
Hannah V McCueInstitute of Systems, Molecular and Integrative Biology, University of Liverpool Crown Street Liverpool L69 7ZB UK.
Sophie R MarriottDepartment of Life Sciences, University of Lincoln Lincoln LN6 7TS UK etaylor@lincoln.ac.uk.
Richard C WilsonDepartment of Life Sciences, University of Lincoln Lincoln LN6 7TS UK etaylor@lincoln.ac.uk.
Justin PerryHub for Biotechnology in Build Environment, Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University Newcastle upon Tyne NE1 8ST UK gary.black@northumbria.ac.uk.ORCID https://orcid.org/0000-0002-3436-0093
Johan P TurkenburgStructural Biology Laboratory, Department of Chemistry, University of York YO10 5DD UK.
Kshatresh D DubeyDepartment of Chemistry, Center for Informatics, School of Natural Sciences, Shiv Nadar University Uttar Pradesh-201314 India.
Stephen H PriorSchool of Chemistry, University of Lincoln Lincoln LN6 7DL UK.
Andrew J CarnellDepartment of Chemistry, University of Liverpool Crown Street Liverpool L69 7ZD UK.
Edward J TaylorDepartment of Life Sciences, University of Lincoln Lincoln LN6 7TS UK etaylor@lincoln.ac.uk.
Gary W BlackHub for Biotechnology in Build Environment, Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University Newcastle upon Tyne NE1 8ST UK gary.black@northumbria.ac.uk.ORCID https://orcid.org/0000-0003-3697-0714
Northumbria University · GBUniversity of Lincoln · GBUniversity of Liverpool · GBShiv Nadar University · INUniversity of York · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The selective α,β-desaturation of cyclic carbonyl compounds, which are found in the core of many steroid and bioactive molecules, using green chemistry is highly desirable. To achieve this task, we have for the first time described and solved the

Identifiers

PMID38550701
PMCPMC10966990
OpenAlexW4392014311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.