Evidence map›Paper›PMID 38550270›Full record

ArticleInternational journal of cardiology. Congenital heart disease2024

Sudden death in adults with repaired coarctation of the aorta: A case for sex-based risk factors.

Lauren Lastinger, Marc Lee, Lauren Hassen, Omer Cavus, Saurabh Rajpal, Jeremy P Moore, May Ling Mah, Elisa A Bradley

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology. Congenital heart disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Lauren LastingerThe Ohio State University, Department of Internal Medicine, Division of Cardiovascular Medicine, Columbus, OH, USA.
Marc LeeThe Heart Center, Nationwide Children's Hospital, Columbus, OH, USA.
Lauren HassenThe Ohio State University, Department of Internal Medicine, Division of Cardiovascular Medicine, Columbus, OH, USA.
Omer CavusThe Ohio State University, Department of Internal Medicine, Division of Cardiovascular Medicine, Columbus, OH, USA.
Saurabh RajpalThe Ohio State University, Department of Internal Medicine, Division of Cardiovascular Medicine, Columbus, OH, USA.
Jeremy P MooreDivision of Cardiology, Ahmanson/UCLA Adult Congenital Heart Disease Center, Department of Medicine, University of California Los Angeles Medical Center, Los Angeles, California, USA.
May Ling MahThe Heart Center, Nationwide Children's Hospital, Columbus, OH, USA.
Elisa A BradleyThe Ohio State University, Department of Internal Medicine, Division of Cardiovascular Medicine, Columbus, OH, USA.
The Ohio State University · USNationwide Children's Hospital · USPenn State Milton S. Hershey Medical Center · USUCLA Health · US

Funding

Defining New Pathways for Complex Human Heart Failure and ArrhythmiaK08HL148701 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI BRADLEY, ELISA ANN · 2020 to 2024
$805k
NHLBI NIH HHS K08 HL148701
6 · The paper itself

Abstract

Background: Sudden cardiac death (SCD) is an important risk for adults with repaired coarctation of the aorta (rCoA). We aimed determine if there are clinical risk factors for SCD in adults with rCoA. Methods and results: SCD events and clinical data from all adults with rCoA at a tertiary care center (2007-2017) were evaluated. In 167 adults with rCoA (39 ± 11 years old, 75 (45%) female) SCD occurred in 8 (5%) (vs. age-matched adults 0.9%). Those with SCD demonstrated significant QTc prolongation (QTc: 479 ± 16 vs. 434 ± 30 msec, p < 0.001). Overall, adults with rCoA and a prolonged sex-normative QTc interval had a 12-fold increased risk of SCD (x Conclusions: There is an unanticipated high burden of SCD in adults with rCoA, occurring in men at younger age than women, suspicious for primary electrophysiologic dysfunction. Future investigation of sex-specific SCD risk in rCoA is important to better understand this disease and its late phenotype.

Indexed as

Adult congenital heart DiseaseCoarctation of the aortaCongenital heart diseaseLate survivalSudden cardiac deathSurvival

Identifiers

PMID38550270
PMCPMC10976478
OpenAlexW4392135519

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.