Evidence map›Paper›PMID 38549836›Full record

ArticleOsteoarthritis imaging2024

Ultrasound-detected effusion-synovitis is associated with greater limb loading rate asymmetry during walking post-ACL reconstruction: A pilot study.

Matthew S Harkey, Corey D Grozier, Jessica Tolzman, Arjun Parmar, Molly Fagan, Katherine Collins, Christopher Kuenze, Ryan Fajardo

Open access · hybridAbstract read
In one paragraph

Article in Osteoarthritis imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Matthew S HarkeyMichigan State University, 308W. Circle Drive 112, East Lansing 48824, MI, United States.
Corey D GrozierMichigan State University, 308W. Circle Drive 112, East Lansing 48824, MI, United States.
Jessica TolzmanMichigan State University, 308W. Circle Drive 112, East Lansing 48824, MI, United States.
Arjun ParmarMichigan State University, 308W. Circle Drive 112, East Lansing 48824, MI, United States.
Molly FaganGrand Valley State University, United States.
Katherine CollinsUniversity of North Carolina at Chapel Hill, United States.
Christopher KuenzeUniversity of Virginia, United States.
Ryan FajardoLansing Radiology Associates, United States.
Michigan State University · USGrand Valley State University · USRadiology Associates · USUniversity of North Carolina at Chapel Hill · USUniversity of Virginia · US

Funding

Walk this Way: Physical Activity and Walking Biomechanics Lead to Early Knee OA Symptoms and Ultrasound-Detected Structural Pathology after ACL ReconstructionK01AR081389 · NIAMS · MICHIGAN STATE UNIVERSITY · PI Matthew Harkey · 2022 to 2026
$689k
NIAMS NIH HHS K01 AR081389
6 · The paper itself

Abstract

Objective: Chronic inflammation and altered walking biomechanics are common after ACL reconstruction (ACLR) and contribute to the development of osteoarthritis. Clinically accessible techniques are needed to monitor inflammation (ultrasound-assessed effusion-synovitis) and walking biomechanics (force-measuring insoles), and they must improve the translation of these assessments and determine whether inflammation and walking biomechanics are related in patients after ACLR. This study aimed to determine the association between ultrasound-detected knee effusion-synovitis and limb loading asymmetries during walking in patients 1-5 years post-ACLR. Design: 15 participants (9 women; age: 26 ± 6yrs; mass: 71 ± 15 kg; height: 173 ± 9 cm; months post-ACLR: 29 ± 13) were included in this cross-sectional study. Knee effusion-synovitis was assessed using a standardized protocol and graded using a validated scoring atlas (0 = absent, 1 = mild, 2 = moderate, 3 = severe) in the ACLR limb. Force-measuring insoles were used to capture the vertical ground reaction force (vGRF) during a one-minute treadmill walking trial. Limb symmetry indices (LSIs) were used to quantify limb loading asymmetry for the peak vGRF and the instantaneous loading rate (vGRF-LR). Spearman correlations determined whether effusion-synovitis grade was associated with peak vGRF and vGRF-LR LSI. Results: Effusion-synovitis was present in the ACLR limb of 13/15 (87 %) participants (Grade 0: Conclusion: Most participants 1-5 years post-ACLR have ultrasound-detected effusion-synovitis. Participants with more severe effusion-synovitis load their ACLR limb more rapidly. This study highlights the utility of clinically accessible techniques in assessing inflammation and walking biomechanics in ACLR patients.

Indexed as

BiomechanicsEarly osteoarthritisGaitInflammationKnee

Identifiers

PMID38549836
PMCPMC10976353
OpenAlexW4391691005

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.