Evidence map›Paper›PMID 38549715›Full record

ArticleMediators of inflammation2024

The Association between Serum Level of Vitamin D and Inflammatory Biomarkers in Hospitalized Adult Patients: A Cross-Sectional Study Based on Real-World Data.

Xiaomin Zhang, Zhiqi Chen, Yi Xiang, Yiquan Zhou, Molian Tang, Jun Cai, Xinyi Xu, Hongyuan Cui, Yi Feng, Renying Xu

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Xiaomin ZhangDepartment of Clinical Nutrition, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.ORCID https://orcid.org/0000-0002-1231-3632
Zhiqi ChenDepartment of Clinical Nutrition, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.ORCID https://orcid.org/0009-0001-9111-0197
Yi XiangDepartment of Clinical Nutrition Center, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.ORCID https://orcid.org/0000-0003-2802-7283
Yiquan ZhouDepartment of Clinical Nutrition, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.ORCID https://orcid.org/0000-0003-1129-8546
Molian TangDepartment of Clinical Nutrition, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.ORCID https://orcid.org/0009-0002-2390-1728
Jun CaiDepartment of Clinical Nutrition, Long Hua Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200031, China.ORCID https://orcid.org/0009-0008-5245-1205
Xinyi XuUniversity of Michigan, LSA 500 S, State Street, Ann Arbor, MI 48109, USA.ORCID https://orcid.org/0009-0002-4958-7562
Hongyuan CuiDepartment of General Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing 100730, China.ORCID https://orcid.org/0000-0003-4930-1608
Yi FengDepartment of Clinical Nutrition Center, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.ORCID https://orcid.org/0000-0002-3725-9644
Renying XuDepartment of Clinical Nutrition, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.ORCID https://orcid.org/0000-0003-2608-5586
Shanghai Jiao Tong University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNShanghai University of Traditional Chinese Medicine · CNState Street (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The association between vitamin D status and inflammation remains unclear in hospitalized patients. Materials and Methods: We performed the current study based on real-world data from two teaching hospitals. Serum level of vitamin D (assessed by 25-hydroxyvitamin D) was evaluated within 2 days after admission. All the patients were further classified into three groups: deficiency (<12 ng/mL), insufficiency (12-20 ng/mL), and adequate (≥20 ng/mL). White blood cell (WBC) count, serum level of C-reactive protein (CRP), and procalcitonin were also measured and used to evaluate inflammation. Other potential covariates were abstracted from medical records. Charlson comorbidity index (CCI) was calculated to assess the severity of disease. Results: A total number of 35,528 hospitalized adult patients (21,171 men and 14,357 women) were included. The average age and BMI were 57.5 ± 16.2 years and 23.4 ± 3.7 kg/m Conclusions: The deficiency and insufficiency of vitamin D in the hospitalized adult patients was very common. However, the results should be interpreted with caution for limited representation of the whole inpatients. Low level of vitamin D was associated with inflammatory biomarkers, which provide the evidences to early intervention for lower the risk of infection.

Indexed as

Vitamin D DeficiencyAdultBiomarkersC-Reactive ProteinCross-Sectional StudiesFemaleHumansInflammationMaleProcalcitoninVitamin DBiomarkersC-Reactive ProteinProcalcitoninVitamin D

Identifiers

PMID38549715
PMCPMC10978080
OpenAlexW4394759454

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.