Evidence map›Paper›PMID 38549681›Full record

ArticleJACC. Advances2024

Impact of Cardiac Magnetic Resonance Left Atrial Ejection Fraction in Advanced Ischemic Cardiomyopathy.

Chris M Anthony, Tom Kai Ming Wang, Donna Salam, Nancy Obuchowski, Mustafa Turkmani, Danah Al-Deiri, Zoran Popovic, Brian Griffin, Scott Flamm, David Chen and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Chris M AnthonyDepartment of Cardiology, The Alfred Hospital, Melbourne, Australia.
Tom Kai Ming WangHeart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Donna SalamHeart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Nancy ObuchowskiHeart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Mustafa TurkmaniInternal Medicine, McLaren Oakland Program, Pontiac, Michigan, USA.
Danah Al-DeiriHeart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Zoran PopovicHeart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Brian GriffinHeart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Scott FlammImaging Institute, Cleveland Clinic, Cleveland, Ohio, USA.
David ChenHeart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Christopher NguyenHeart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Wilson W H TangHeart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Deborah KwonHeart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Cleveland Clinic · USMcLaren Health Care · USThe Alfred Hospital · AU

Funding

Improving Phenotypic Classification and Prediction of Treatment Outcomes in Patients with Non-ischemic Cardiomyopathy and Functional Mitral RegurgitationR01HL170090 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI DEBORAH KWON · 2023 to 2026
$3.1M
NHLBI NIH HHS R01 HL170090
6 · The paper itself

Abstract

backgroundThe prognostic significance of cardiac magnetic resonance (CMR)-based left atrial ejection fraction (LAEF) is not well defined in the ischemic cardiomyopathy (ICM) cohort.

objectivesThe authors sought to assess the prognostic impact of LAEF, when adjusted for left ventricular remodeling, myocardial infarct size (MIS), left atrial volume index, and functional mitral regurgitation (FMR), on outcomes in patients with advanced ICM.

methodsICM patients who underwent CMR were retrospectively evaluated (April 2001-December 2019). LAEF, left atrial volume index, MIS, left ventricular remodeling, and FMR were derived from CMR. The primary clinical endpoint was a composite of all-cause mortality and cardiac transplant. A baseline multivariable Cox proportional hazards regression model was constructed to assess prognostic power of LAEF.

resultsThere were 718 patients (416 primary events) evaluated, with a median duration of follow-up of 1,763 days (4.8 years) and a mean LAEF of 36% ± 15%. On multivariable analysis, higher LAEF was independently associated with reduced risk (HR: 0.24, 95% CI: 0.12-0.48,

conclusionsReduced LAEF is independently associated with increased mortality in ICM. Risk associated with declining LAEF is continuous and incremental to other risk factors for adverse outcomes in patients with ICM even after adjusting for MIS and FMR severity.

Indexed as

ischemic cardiomyopathyleft atrial ejection fractionpatient factors and left atrial functionprognostic indices in advanced ICM

Identifiers

PMID38549681
PMCPMC10977265
OpenAlexW4390597936

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.