Evidence map›Paper›PMID 38549144›Full record

ArticleJournal of neuroinflammation2024

The immunomodulatory effect of oral NaHCO

Milena Rodriguez Alvarez, Hussam Alkaissi, Aja M Rieger, Guillem R Esber, Manuel E Acosta, Stacy I Stephenson, Allison V Maurice, Laura Melissa Rodríguez Valencia, Christopher A Roman, Juan Marcos Alarcon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Milena Rodriguez AlvarezSchool of Graduate Studies & Department of Internal Medicine, Division of Rheumatology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA. Milena.rodriguezalvarez@downstate.edu.ORCID http://orcid.org/0000-0002-2845-5766
Hussam AlkaissiDivision of Diabetes, Endocrinology, and Metabolic Diseases, NIH/NIDDK, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-0861-9348
Aja M RiegerDepartment of Medical Microbiology and Immunology, University of Alberta, Alberta, Canada.ORCID http://orcid.org/0000-0002-0536-6023
Guillem R EsberCenter for Studies in Behavioral Neurobiology, Concordia University, Montreal, Canada.ORCID http://orcid.org/0000-0001-8874-4255
Manuel E AcostaMathematics and Computer Sciences Department, Barry University, Miami, FL, USA.
Stacy I StephensonDivision of Comparative Medicine, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.ORCID http://orcid.org/0000-0002-7064-0113
Allison V MauriceDivision of Comparative Medicine, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Laura Melissa Rodríguez ValenciaDepartment of Anesthesiology, Downstate Health Sciences University, Brooklyn, NY, USA.ORCID http://orcid.org/0000-0002-3818-9553
Christopher A RomanDepartment of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.ORCID http://orcid.org/0000-0001-8366-2891
Juan Marcos AlarconDepartment of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.ORCID http://orcid.org/0000-0002-3936-806X
SUNY Downstate Health Sciences University · USBarry University · USConcordia University · CANational Institute of Diabetes and Digestive and Kidney Diseases · USUniversity of Alberta · CA

Funding

TRANSPORT - the TRANSlational Program Of health disparities Research TrainingS21MD012474 · NIMHD · SUNY DOWNSTATE MEDICAL CENTER · PI Carla Boutin-Foster, William Marcus Lambert · 2017 to 2026
$18.0M
Experience-dependent Modulation of Synaptic Circuits in the HippocampusR21NS091830 · NINDS · SUNY DOWNSTATE MEDICAL CENTER · PI ALARCON, JUAN MARCOS · 2015 to 2016
$456k
NIMHD NIH HHS 5S21MD012474-02NIMHD NIH HHS S21 MD012474NINDS NIH HHS R21 NS091830NINDS NIH HHS R21NS091830
6 · The paper itself

Abstract

Stimulation of the inflammatory reflex (IR) is a promising strategy for treating systemic inflammatory disorders. Recent studies suggest oral sodium bicarbonate (NaHCO

Indexed as

SpleenVagus NerveAnimalsAnti-Inflammatory AgentsFemaleImmunomodulationMacrophagesRatsAnti-Inflammatory AgentsArtificial neural networksCholinergic splenic anti-inflammatory pathway (CSAP)Inflammatory reflex (IR)Sodium bicarbonate (NaHCO3)Splanchnic anti-inflammatory pathways (SAP)Spleen denervationSplenic nerveVagal nerve stimulation (VNS)

Identifiers

PMID38549144
PMCPMC10976719
OpenAlexW4393262822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.