ReviewKnee surgery & related research2024
Effects of concurrent cartilage procedures on cartilage regeneration in high tibial osteotomy: a systematic review.
Review in Knee surgery & related research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 14 citations in OpenAlex.
- Particulated Costal Hyaline Cartilage Allograft and Microdrilling Combined with High Tibial Osteotomy Improves Early Pain Outcomes in Patients Suffering from Medial Knee Osteoarthritis with Full-Thickness Cartilage Defects: A Randomized Controlled Trial.Medicina (Kaunas, Lithuania) · 2026Trial
- MOCART 2.0 score of 60 or greater measured at 1 year post-operatively predicts favourable clinical outcomes after surgical repair of tibiofemoral cartilage lesions.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Autologous collagen-induced chondrogenesis versus mesenchymal stem cell therapy combined with high tibial osteotomy for medial knee osteoarthritis: a retrospective study.Stem cell research & therapy · 2026Article
- Concomitant arthroscopy during valgus-producing high tibial osteotomy does not demonstrate consistent additional clinical benefit despite improved cartilage findings: A systematic review of comparative studies.Journal of experimental orthopaedics · 2026Review
- Structural Gains Without Symptomatic Benefit After Microfracture During High Tibial Osteotomy.Orthopaedic journal of sports medicine · 2026Article
- Combined Cartilage Procedures After High Tibial Osteotomy: Cartilage Status, Early Functional Recovery, and Short-term Clinical Outcomes.Orthopaedic journal of sports medicine · 2026Article
- Factors affecting outcomes of intra-articular injection of autologous, culture-expanded, adipose-derived mesenchymal stem cells in knee osteoarthritis.Stem cells translational medicine · 2026Observational
- Review
- Improved Coronal Alignment Using the Preemptive Joint Line Convergence Angle Compensation Method in Medial Open Wedge High Tibial Osteotomy: A Retrospective Propensity Score-Matched Analysis.Orthopaedic journal of sports medicine · 2026Article
- Comparison of a patient-specific instrument and conventional high tibial Osteotomy: Accuracy of correction target and prevention of posterior tibial slope change.Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology · 2025Article
- Distal tubercle osteotomy in medial opening-wedge high tibial osteotomy is superior in rotational alignment changes compared to proximal tubercle osteotomy: a propensity score-matched analysis.Journal of orthopaedic surgery and research · 2025Article
- Hepatocyte Growth Factor-Mediated Chondrocyte Proliferation Induced by Adipose-Derived MSCs from Osteoarthritis Patients and Its Synergistic Enhancement by Hyaluronic Acid.International journal of molecular sciences · 2025Article
- Combined High Tibial Osteotomy and Transtibial Drilling of Tibial and Femoral Medial Compartment Cartilage Defect of the Knee.Arthroscopy techniques · 2025Article
- Comparison of Proximal Tibiofibular Joint Detachment with Tibial-Sided Osteotomy for Fibular Untethering in Lateral Closing-Wedge High Tibial Osteotomy: A Cadaveric Study.Medicina (Kaunas, Lithuania) · 2025Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis systematic review aimed to evaluate the effects of concurrent cartilage procedures on cartilage regeneration when performed alongside high tibial osteotomy (HTO). MATERIALS AND
methodsThe systematic review followed the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). A comprehensive search was conducted on databases including PubMed, Embase, Cochrane Library, and Google Scholar, covering articles published until August 31, 2023.
resultsSixteen studies (1277 patients) revealed that HTO, with or without concurrent cartilage procedures, leads to cartilage regeneration based on the International Cartilage Repair Society (ICRS) grade during second-look arthroscopy. No concurrent procedure showed improvement in ICRS grade (mean difference: - 0.80 to - 0.49). Microfracture (mean difference: - 0.75 to - 0.22), bone marrow aspirate concentrate (BMAC) (mean difference: - 1.37 to - 0.67), and human umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC) (mean difference: - 2.46 to - 1.81) procedures also demonstrated positive outcomes. Clinical outcome assessments for each cartilage procedure were also improved during postoperative follow-up, and no specific complications were reported.
conclusionsHTO with or without concurrent cartilage procedures promotes cartilage regeneration observed during second-look arthroscopy, with improved clinical outcomes. Future randomized controlled trials on the same topic, along with subsequent meta-analyses, are necessary for conclusive findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.