Evidence map›Paper›PMID 38548949›Full record

Observational studyCanadian journal of anaesthesia = Journal canadien d'anesthesie2024

Venous congestion in septic shock quantified with point-of-care ultrasound: a pilot prospective multicentre cohort study.

Ross Prager, Robert Arntfield, Michelle Y S Wong, Ian Ball, Kimberley Lewis, Bram Rochwerg, John Basmaji

Registry-linked trialOpen access · bronzeAbstract readObservational StudyMulticenter Study
PubMed Publisher
In one paragraph

Observational study in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07291778 (The Impact of VeXUS-guided Fluid Management in ICU Populations on Renal Function), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
18.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07291778 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Impact of VeXUS-guided Fluid Management in ICU Populations on Renal Function

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2026 to 2028Enrolled100ConditionsAcute Kidney Injury, VExUSArmsFluid Management, No intervention
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 32 citations in OpenAlex.

  1. Characterizing the molecular landscape of venous congestion.World journal of critical care medicine · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Observational
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ross PragerDivision of Critical Care, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Robert ArntfieldDivision of Critical Care, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Michelle Y S WongDivision of Critical Care, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. ywong252@uwo.ca.ORCID 0000-0002-2306-5611
Ian BallDivision of Critical Care, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Kimberley LewisDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Bram RochwergDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
John BasmajiDivision of Critical Care, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Western University · CAImpact · CA

Funding

Physicians of Ontario R22-32
6 · The paper itself

Abstract

purposeVenous congestion is a pathophysiologic state that can result in organ dysfunction, particularly acute kidney injury (AKI). We sought to evaluate the feasibility of performing a definitive observational study to determine the impact of venous congestion quantified using point-of-care ultrasound (POCUS) in patients with septic shock.

methodsWe conducted a prospective observational feasibility study at two intensive care units (ICUs). We recruited adult patients with septic shock within 12 hr of ICU admission. Using the validated Venous Excess Ultrasound Score (VEXUS), we quantified venous congestion on day 1 and day 3 of ICU admission. The primary feasibility outcome was successful completion rate of the two VEXUS scores. We performed a survival analysis to quantify the hazard of renal replacement therapy (RRT).

resultsWe enrolled 75 patients from January 2022 to January 2023. The success rate of completion for VEXUS scans was 94.5% (95% confidence interval [CI], 89.5 to 97.6). Severe venous congestion was present in 19% (14/75) of patients on ICU admission day 1 and in 16% (10/61) of patients on day 3. Venous congestion on ICU admission may be associated with a higher risk of requiring RRT (unadjusted hazard ratio, 3.35; 95% CI, 0.94 to 11.88; P = 0.06).

conclusionsIt is feasible to conduct a definitive observational study exploring the association between venous congestion quantified with POCUS and clinical outcomes in patients with septic shock. We hypothesize that venous congestion may be associated with an increased hazard of receiving RRT.

Indexed as

Acute Kidney InjuryHyperemiaShock, SepticAdultHumansIntensive Care UnitsPoint-of-Care SystemsProspective StudiesRenal Replacement Therapyacute kidney injuryAKIPOCUSpoint-of-care ultrasoundrenal replacement therapyvenous congestion

Identifiers

PMID38548949
OpenAlexW4393250852

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.