Evidence map›Paper›PMID 38548937›Full record

ArticleNature protocols2024

A practical guide for the preparation of C1-labeled α-amino acids using aldehyde catalysis with isotopically labeled CO

Michael G J Doyle, Braeden A Mair, Anna Sib, Odey Bsharat, Maxime Munch, Volker Derdau, Benjamin H Rotstein, Rylan J Lundgren

Abstract read
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In one paragraph

Article in Nature protocols, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michael G J DoyleDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-7990-6600
Braeden A MairDepartment of Biochemistry, Microbiology and Immunology and Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada.
Anna SibSanofi Germany, R&D, Integrated Drug Discovery, Isotope Chemistry, Industriepark Höchst, Frankfurt, Germany.
Odey BsharatDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada.
Maxime MunchDepartment of Biochemistry, Microbiology and Immunology and Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada.
Volker DerdauSanofi Germany, R&D, Integrated Drug Discovery, Isotope Chemistry, Industriepark Höchst, Frankfurt, Germany.
Benjamin H RotsteinDepartment of Biochemistry, Microbiology and Immunology and Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada. Benjamin.Rotstein@uottawa.ca.ORCID 0000-0001-9707-9357
Rylan J LundgrenDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada. rylan.lundgren@ualberta.ca.ORCID 0000-0002-7760-6946

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Isotopically carbon-labeled α-amino acids are valuable synthetic targets that are increasingly needed in pharmacology and medical imaging. Existing preparations rely on early stage introduction of the isotopic label, which leads to prohibitive synthetic costs and time-intensive preparations. Here we describe a protocol for the preparation of C1-labeled α-amino acids using simple aldehyde catalysts in conjunction with [*C]CO

Indexed as

AldehydesAmino AcidsCarbon DioxideCarbon IsotopesIsotope LabelingCarbon RadioisotopesCatalysisPhenylalanineAldehydesAmino AcidsCarbon DioxideCarbon IsotopesCarbon RadioisotopesPhenylalanine

Identifiers

PMID38548937

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.