Evidence map›Paper›PMID 38548902›Full record

ArticleCommunications biology2024

The nuclear import receptor Kapβ2 modifies neurotoxicity mediated by poly(GR) in C9orf72-linked ALS/FTD.

M E Cicardi, V Kankate, S Sriramoji, K Krishnamurthy, S S Markandaiah, B M Verdone, A Girdhar, A Nelson, L B Rivas, A Boehringer and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Targeting GeneInternational journal of molecular sciences · 2025
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

M E CicardiWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0001-9490-303X
V KankateWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
S SriramojiWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
K KrishnamurthyWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0003-2552-8912
S S MarkandaiahWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
B M VerdoneWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
A GirdharDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.
A NelsonWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
L B RivasWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0002-8878-3729
A BoehringerWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
A R HaeuslerWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0001-5566-3707
P PasinelliWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
L GuoDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA. lin.guo@jefferson.edu.ORCID 0000-0002-2589-9513
D TrottiWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA. davide.trotti@jefferson.edu.ORCID 0000-0001-6338-6404
Thomas Jefferson University · US

Funding

Exosome-mediated propagation of disease linked poly-dipeptides in C9orf72-FTD/ALSRF1AG057882 · NIA · THOMAS JEFFERSON UNIVERSITY · PI TROTTI, DAVIDE, YANG, YONGJIE · 2018 to 2018
$3.6M
Elucidating the Mechanism in the Regulation of RNA-binding Protein Phase SeparationR35GM138109 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI Lin Guo · 2020 to 2026
$2.6M
The pathogenic relationship between neuronal activity and C9orf72-linked neurodegenerationRF1NS114128 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI HAEUSLER, AARON RAYMOND · 2020 to 2021
$2.5M
Contribution of astrocytes to mutant FUS-linked Amyotrophic Lateral SclerosisR01NS109150 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI PASINELLI, PIERA · 2019 to 2023
$1.7M
The pathogenic relationship between neuronal activity and C9orf72-linked neurodegenerationR01NS114128 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI HAEUSLER, AARON RAYMOND · 2024 to 2024
$537k
Development of a mouse model of C9ORF72 ALS/FTD expressing RAN translated peptideR21NS090912 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI TROTTI, DAVIDE · 2014 to 2015
$428k
NIA NIH HHS RF1 AG057882NIGMS NIH HHS R35 GM138109NINDS NIH HHS R01 NS109150NINDS NIH HHS R01 NS114128NINDS NIH HHS R21 NS090912NINDS NIH HHS RF1 NS114128
6 · The paper itself

Abstract

Expanded intronic G

Indexed as

Amyotrophic Lateral SclerosisFrontotemporal DementiaActive Transport, Cell NucleusC9orf72 ProteinDNA-Binding ProteinsHumansReceptors, Cytoplasmic and NuclearC9orf72 ProteinC9orf72 protein, humanDNA-Binding ProteinsReceptors, Cytoplasmic and Nuclear

Identifiers

PMID38548902
PMCPMC10978903
OpenAlexW4393253131

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.