Evidence map›Paper›PMID 38548886›Full record

ArticleCommunications biology2024

GFI1B and LSD1 repress myeloid traits during megakaryocyte differentiation.

Jeron Venhuizen, Maaike G J M van Bergen, Saskia M Bergevoet, Daan Gilissen, Cornelia G Spruijt, Laura Wingens, Emile van den Akker, Michiel Vermeulen, Joop H Jansen, Joost H A Martens and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jeron Venhuizen *Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Research Institute for Medical Innovation, Nijmegen, The Netherlands.ORCID 0000-0002-8402-3466
Maaike G J M van Bergen *Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Research Institute for Medical Innovation, Nijmegen, The Netherlands.
Saskia M BergevoetDepartment of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Research Institute for Medical Innovation, Nijmegen, The Netherlands.
Daan GilissenDepartment of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Research Institute for Medical Innovation, Nijmegen, The Netherlands.ORCID 0000-0003-1465-3400
Cornelia G SpruijtDepartment of Molecular Biology, Faculty of Science, Oncode Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.
Laura WingensDepartment of Molecular Developmental Biology, Faculty of Science, Radboud University Nijmegen, Nijmegen, The Netherlands.ORCID 0000-0001-8348-5979
Emile van den AkkerDepartment of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-2596-0046
Michiel VermeulenDepartment of Molecular Biology, Faculty of Science, Oncode Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.ORCID 0000-0003-0836-6894
Joop H JansenDepartment of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Research Institute for Medical Innovation, Nijmegen, The Netherlands.
Joost H A MartensDepartment of Molecular Biology, Faculty of Science, Oncode Institute, Radboud University Nijmegen, Nijmegen, The Netherlands. joost.martens@ru.nl.ORCID 0000-0003-2008-6537
Bert A van der ReijdenDepartment of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Research Institute for Medical Innovation, Nijmegen, The Netherlands. Bert.vanderReijden@radboudumc.nl.ORCID 0000-0001-7804-8643
Radboud University Nijmegen · NLSanquin · NL

Funding

Landsteiner Foundation for Blood Transfusion Research (LSBR) 1531
6 · The paper itself

Abstract

The transcription factor Growth Factor Independence 1B (GFI1B) recruits Lysine Specific Demethylase 1 A (LSD1/KDM1A) to stimulate gene programs relevant for megakaryocyte and platelet biology. Inherited pathogenic GFI1B variants result in thrombocytopenia and bleeding propensities with varying intensity. Whether these affect similar gene programs is unknow. Here we studied transcriptomic effects of four patient-derived GFI1B variants (GFI1B

Indexed as

HematopoiesisMegakaryocytesCell DifferentiationGene Expression RegulationHistone DemethylasesHumansProto-Oncogene ProteinsRepressor ProteinsGFI1B protein, humanHistone DemethylasesKDM1A protein, humanProto-Oncogene ProteinsRepressor Proteins

Identifiers

PMID38548886
PMCPMC10978956
OpenAlexW4393260091

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.