Evidence map›Paper›PMID 38548864›Full record

Observational studySpinal cord2024

Assessment of renal function in persons with motor complete spinal cord injury-cystatin C as an accurate single marker.

Thomas Anand Augustine, Henry Prakash M, Suceena Alexander, Mahasampath Gowri S

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Spinal cord, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Thomas Anand AugustineDepartment of Physical Medicine and Rehabilitation, Christian Medical College Vellore, Vellore, India.ORCID 0009-0007-3528-7768
Henry Prakash MDepartment of Physical Medicine and Rehabilitation, Christian Medical College Vellore, Vellore, India. henry.cmcv@gmail.com.ORCID 0000-0002-0015-3563
Suceena AlexanderDepartment of Nephrology, Christian Medical College Vellore, Vellore, India.
Mahasampath Gowri SDepartment of Biostatistics, Christian Medical College Vellore, Vellore, India.
Christian Medical College, Vellore · IN

Funding

Christian Medical College, Vellore (CMC Vellore) IRB Min.No 11341DBT-Wellcome Trust India Alliance IA/CPHS/22/1/506541
6 · The paper itself

Abstract

STUDY

designObservational cohort.

aimTo show that Cystatin C is an accurate single marker to estimate GFR in motor complete persons with SCI.

objectivesTo assess if Cystatin C is an accurate for estimating GFR in persons with SCI with no preserved motor power. To study if use of Serum creatinine for estimation of GFR in this population significantly overestimates GFR, thereby inaccurate.

settingTertiary care hospital and Medical College, Vellore, South India.

methods30 persons with SCI (ASIA A and B) fulfilling the inclusion criteria were recruited. Serum Creatinine and Serum Cystatin C values were obtained, and eGFR was calculated based on available formulae. 24-h urine for urine creatinine clearance-based eGFR was used as a reference value.

resultsAnalysis with a Bland-Atman plot showed that eGFR estimated with Serum Cystatin C was more accurate than Serum Creatinine, using 24-h urine creatinine as a reference value. eGFR using Serum Creatinine significantly overestimated GFR by over 50.6%. Estimated GFR using Serum Cystatin C showed a meager mean difference of 0.5% from the reference 24-h urine creatinine clearance (mean difference of -2.56%).

conclusionSerum Cystatin C is a much more accurate marker for estimating GFR in SCI, compared to serum Creatinine which overestimates GFR.

Indexed as

BiomarkersCreatinineCystatin CGlomerular Filtration RateSpinal Cord InjuriesAdultCohort StudiesFemaleHumansKidney Function TestsMaleMiddle AgedYoung AdultBiomarkersCreatinineCystatin C

Identifiers

PMID38548864
PMCPMC7616118
OpenAlexW4393261924

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.