Evidence map›Paper›PMID 38548777›Full record

ArticleScientific reports2024

Diving into the proteomic atlas of SARS-CoV-2 infected cells.

Victor C Carregari, Guilherme Reis-de-Oliveira, Fernanda Crunfli, Bradley J Smith, Gabriela Fabiano de Souza, Stéfanie Primon Muraro, Veronica M Saia-Cereda, Pedro H Vendramini, Paulo A Baldasso, Lícia C Silva-Costa and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Victor C Carregari *Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil. corasolla@gmail.com.
Guilherme Reis-de-Oliveira *Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Fernanda CrunfliLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Bradley J SmithLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Gabriela Fabiano de SouzaLaboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), São Paulo, Brazil.
Stéfanie Primon MuraroLaboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), São Paulo, Brazil.
Veronica M Saia-CeredaLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Pedro H VendraminiLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Paulo A BaldassoLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Lícia C Silva-CostaLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Giuliana S ZuccoliLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Caroline Brandão-TelesLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
André AntunesLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Aline F ValençaLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Gustavo G DavanzoLaboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), São Paulo, Brazil.
João Victor Virgillio-da-SilvaDepartment of Pharmacology, Ribeirão Preto Medical School (FMRP), University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
Thiago Dos Reis AraújoObesity and Comorbidities Research Center (OCRC), Campinas, São Paulo, Brazil.
Raphael Campos GuimarãesCenter for Research in Inflammatory Diseases, Ribeirão Preto, SP, Brazil.
Felipe David Mendonça ChaimDepartment of Surgery, Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.
Elinton Adami ChaimDepartment of Surgery, Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.
Carolina Mie Kawagosi OnoderaHematology-Hemotherapy Center, University of Campinas, Campinas, SP, Brazil.
Raissa Guimarães LudwigDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Tatiana Dandolini SacconDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
André R L DamásioDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Luiz Osório S LeiriaDepartment of Pharmacology, Ribeirão Preto Medical School (FMRP), University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
Marco Aurélio R VinoloObesity and Comorbidities Research Center (OCRC), Campinas, São Paulo, Brazil.
Alessandro S FariasInstituto Nacional de Biomarcadores em Neuropsiquiatria (INBION), Conselho Nacional de Desenvolvimento Científico e Tecnológico, São Paulo, 05403-000, Brazil.
Pedro M Moraes-VieiraLaboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), São Paulo, Brazil.
Marcelo A MoriDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
José Luiz P MódenaLaboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), São Paulo, Brazil.
Daniel Martins-de-SouzaLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil. dmsouza@unicamp.br.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 88887·495565/2020-00Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/05155-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/04558-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/04579-7Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/04583-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/04746-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/04919-2Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/05040-4Fundo de Apoio ao Ensino, à Pesquisa e Extensão, Universidade Estadual de Campinas 2274/20
6 · The paper itself

Abstract

The COVID-19 pandemic was initiated by the rapid spread of a SARS-CoV-2 strain. Though mainly classified as a respiratory disease, SARS-CoV-2 infects multiple tissues throughout the human body, leading to a wide range of symptoms in patients. To better understand how SARS-CoV-2 affects the proteome from cells with different ontologies, this work generated an infectome atlas of 9 cell models, including cells from brain, blood, digestive system, and adipocyte tissue. Our data shows that SARS-CoV-2 infection mainly trigger dysregulations on proteins related to cellular structure and energy metabolism. Despite these pivotal processes, heterogeneity of infection was also observed, highlighting many proteins and pathways uniquely dysregulated in one cell type or ontological group. These data have been made searchable online via a tool that will permit future submissions of proteomic data ( https://reisdeoliveira.shinyapps.io/Infectome_App/ ) to enrich and expand this knowledgebase.

Indexed as

COVID-19SARS-CoV-2HumansPandemicsProteomics

Identifiers

PMID38548777
PMCPMC10978884

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.