ArticleNature communications2024
Anaerobic fungi in the tortoise alimentary tract illuminate early stages of host-fungal symbiosis and Neocallimastigomycota evolution.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 15 citations in OpenAlex.
- Beyond carbon dioxide: decoupling headspace and buffering reveals a bicarbonate requirement for anaerobic gut fungi growth.Fungal biology and biotechnology · 2026Article
- Animal gut microbes and microbiomes in the 21st century and beyond.Science China. Life sciences · 2026Review
- Description ofInternational journal of systematic and evolutionary microbiology · 2026Article
- Exploring the diversity and community structure of the Testudines fecal mycobiome.bioRxiv : the preprint server for biology · 2026Article
- Behavioral Selection of Coprophagy in an Arid-Adapted Herbivore: Does a Compatibility-Risk Gradient Shape Selective Coprophagy?Ecology and evolution · 2026Article
- Full ribosomal operon sequencing of anaerobic gut fungi (phylumIMA fungus · 2026Article
- Description ofbioRxiv : the preprint server for biology · 2025Article
- Microbial Enrichments Contribute to Characterization Of Desert Tortoise Gut Microbiota.Microbial ecology · 2025Article
- Differential Microbial Composition and Fiber Degradation in Two Sloth Species (Bradypus variegatus and Choloepus hoffmanni).Current microbiology · 2025Article
- Breed-Specific Responses and Ruminal Microbiome Shifts in Dairy Cows Under Heat Stress.Animals : an open access journal from MDPI · 2025Article
- Article
- Anaerobic gut fungal community in ostriches (ISME communications · 2025Article
- Anaerobic fungi in the tortoise alimentary tract illuminate early stages of host-fungal symbiosis and Neocallimastigomycota evolution.Nature communications · 2024Article
- Article
- Evaluating the impact of redox potential on the growth capacity of anaerobic gut fungi.FEMS microbes · 2024Article
- Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Anaerobic gut fungi (AGF, Neocallimastigomycota) reside in the alimentary tract of herbivores. While their presence in mammals is well documented, evidence for their occurrence in non-mammalian hosts is currently sparse. Culture-independent surveys of AGF in tortoises identified a unique community, with three novel deep-branching genera representing >90% of sequences in most samples. Representatives of all genera were successfully isolated under strict anaerobic conditions. Transcriptomics-enabled phylogenomic and molecular dating analyses indicated an ancient, deep-branching position in the AGF tree for these genera, with an evolutionary divergence time estimate of 104-112 million years ago (Mya). Such estimates push the establishment of animal-Neocallimastigomycota symbiosis from the late to the early Cretaceous. Further, tortoise-associated isolates (T-AGF) exhibited limited capacity for plant polysaccharides metabolism and lacked genes encoding several carbohydrate-active enzyme (CAZyme) families. Finally, we demonstrate that the observed curtailed degradation capacities and reduced CAZyme repertoire is driven by the paucity of horizontal gene transfer (HGT) in T-AGF genomes, compared to their mammalian counterparts. This reduced capacity was reflected in an altered cellulosomal production capacity in T-AGF. Our findings provide insights into the phylogenetic diversity, ecological distribution, evolutionary history, evolution of fungal-host nutritional symbiosis, and dynamics of genes acquisition in Neocallimastigomycota.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.