ArticleGut microbes
Integrated analysis of gut metabolome, microbiome, and brain function reveal the role of gut-brain axis in longevity.
Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Effects of Sodium Butyrate on Digestive Metabolism, Blood Gas Parameters and Blood Biochemical Indices in Tumbler Pigeons Based on Untargeted Metabolomics.Animals : an open access journal from MDPI · 2026Article
- Associations Between Complement C4, Habitual Constipation, and Sleep Disturbance in Oldest-Old and Centenarian Chinese Adults.Journal of inflammation research · 2025Article
- Interaction between gut microbiota and anesthesia: mechanism exploration and translation challenges focusing on the gut-brain-liver axis.Frontiers in cellular and infection microbiology · 2025Review
- Beyond the Pillow: Linking Subjective and Objective Sleep Measures to Gut Microbiome Composition in Community-Dwelling Older Adults.Nature and science of sleep · 2025Article
- Disease-driven restructuring of the gut microbiome underlies inflammatory bowel disease dysbiosis.Frontiers in microbiology · 2025Article
- Efficacy and safety ofIndian journal of urology : IJU : journal of the Urological Society of IndiaReview
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Authors and funding
12 authors.
Funding
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Abstract
The role of microbiota-gut-brain axis in modulating longevity remains undetermined. Here, we performed a multiomics analysis of gut metagenomics, gut metabolomics, and brain functional near-infrared spectroscopy (fNIRS) in a cohort of 164 participants, including 83 nonagenarians (NAs) and 81 non-nonagenarians (NNAs) matched with their spouses and offspring. We found that 438 metabolites were significantly different between the two groups; among them, neuroactive compounds and anti-inflammatory substances were enriched in NAs. In addition, increased levels of neuroactive metabolites in NAs were significantly associated with NA-enriched species that had three corresponding biosynthetic potentials:
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Registered trials
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