Evidence map›Paper›PMID 38548291›Full record

ArticleThe European respiratory journal2024

Polysomnographic airflow shapes and site of collapse during drug-induced sleep endoscopy.

Sara Op de Beeck, Daniel Vena, Dwayne Mann, Ali Azarbarzin, Phillip Huyett, Eli Van de Perck, Laura K Gell, Raichel M Alex, Marijke Dieltjens, Marc Willemen and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European respiratory journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Efficacy and durability of palatal surgery in the treatment of simple snoring: a long-term follow-up study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  3. Review
  4. Review
  5. Drug-Induced Sleep Endoscopy in Children Predicts OSA Severity.World journal of otorhinolaryngology - head and neck surgery · 2026
    Article
  6. The upper airway in obstructive sleep apnoea: state of the art.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  7. Observational
  8. The Where and the Why of Obstructive Sleep Apnea.Annals of the American Thoracic Society · 2025
    Article
  9. Observational
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Sara Op de BeeckTranslational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium Sara.opdebeeck@uantwerpen.be.ORCID https://orcid.org/0000-0002-5978-9814
Daniel VenaDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0003-1740-8777
Dwayne MannSchool of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia.ORCID https://orcid.org/0000-0002-2499-5415
Ali AzarbarzinDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0002-4986-4753
Phillip HuyettDepartment of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA.
Eli Van de PerckTranslational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.ORCID https://orcid.org/0000-0002-7180-0473
Laura K GellDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0001-7363-7887
Raichel M AlexDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0002-7544-5595
Marijke DieltjensTranslational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.ORCID https://orcid.org/0000-0002-5822-1960
Marc WillemenMultidisciplinary Sleep Disorders Centre, Antwerp University Hospital, Edegem, Belgium.
Johan VerbraeckenMultidisciplinary Sleep Disorders Centre, Antwerp University Hospital, Edegem, Belgium.ORCID https://orcid.org/0000-0002-6087-678X
Andrew WellmanDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0002-9000-3007
Olivier M VandervekenTranslational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.ORCID https://orcid.org/0000-0002-4088-4213
Scott A SandsDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0003-3752-0328
Brigham and Women's Hospital · USUniversity of Antwerp · BEAntwerp University Hospital · BEMassachusetts Eye and Ear Infirmary · USQueensland University of Technology · AU

Funding

Validation of a Phenotype Model to Predict Response to Alternative OSA TreatmentsR01HL102321 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WELLMAN, DAVID ANDREW · 2011 to 2025
$7.3M
Determination of the site of pharyngeal collapse in Obstructive Sleep Apnea patients from snoring soundsR01HL128658 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WELLMAN, DAVID ANDREW · 2016 to 2025
$4.3M
A Novel Pharmacological Therapy for Obstructive Sleep ApneaR01HL146697 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SANDS, SCOTT A · 2019 to 2023
$3.4M
NHLBI NIH HHS R01 HL102321NHLBI NIH HHS R01 HL128658NHLBI NIH HHS R01 HL146697
6 · The paper itself

Abstract

backgroundDifferences in the pharyngeal site of collapse influence efficacy of non-continuous positive airway pressure therapies for obstructive sleep apnoea (OSA). Notably, complete concentric collapse at the level of the palate (CCCp) during drug-induced sleep endoscopy (DISE) is associated with reduced efficacy of hypoglossal nerve stimulation, but CCCp is currently not recognisable using polysomnography. Here we develop a means to estimate DISE-based site of collapse using overnight polysomnography.

methods182 OSA patients provided DISE and polysomnography data. Six polysomnographic flow shape characteristics (mean during hypopnoeas) were identified as candidate predictors of CCCp (primary outcome variable, n=44/182), including inspiratory skewness and inspiratory scoopiness. Multivariable logistic regression combined the six characteristics to predict clear presence (n=22)

resultsCCCp was characterised by greater scoopiness (β=1.5±0.6 per 2sd, multivariable estimate±se) and skewness (β=11.4±2.4) compared with non-CCCp. The odds ratio for CCCp in predicted positive

conclusionsThe current study provides a means to recognise patients with likely CCCp or other DISE-based site of collapse categories using routine polysomnography. Since site of collapse influences therapeutic responses, polysomnographic airflow shape analysis could facilitate precision site-specific OSA interventions.

Indexed as

EndoscopyPolysomnographySleep Apnea, ObstructiveAdultAgedContinuous Positive Airway PressureEpiglottisFemaleHumansHypoglossal NerveLogistic ModelsMaleMiddle AgedMultivariate AnalysisPalatePharynx

Identifiers

PMID38548291
PMCPMC11154757
OpenAlexW4393254856

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.