ArticleNeuron2024
Monitoring norepinephrine release in vivo using next-generation GRAB
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Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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66citing papers in PubMed
22.5field-weighted citation impact, top 1% of its field
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Who cites it
66 citing papers in PubMed, 86 citations in OpenAlex.
- Modulation of the noradrenergic system using transcranial ultrasonic stimulation targeted to the brainstem locus coeruleus in awake mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Catecholamine metabolism revisited: from neurochemistry to integrative physiology and pathophysiology.Physiological reviews · 2026Review
- Subtype-resolved norepinephrine imaging with an engineered αCell reports methods · 2026Article
- Astrocytic adrenergic α2 receptor contributes to the mechanisms underlying the circadian rhythmicity of seizure susceptibility.Acta pharmacologica Sinica · 2026Article
- Norepinephrine and dopamine sensor crosstalk depends on local innervation density.Nature neuroscience · 2026Article
- Article
- Early life stress induces sex-specific changes in cognitive and affective behavior associated with disrupted noradrenergic physiology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Illuminating the Future of Catecholamine Detection.Journal of neurochemistry · 2026Review
- Red-shifted GRAB acetylcholine sensors for multiplex imaging in vivo.Nature neuroscience · 2026Article
- Extinction-restraint intervention eradicates fear memory encoded in BLA engram cells via D2 receptor-mediated dopaminergic modulation from locus coeruleus.Experimental & molecular medicine · 2026Article
- SENSIT, a Modular Single-Chain Fluorescent Integrator Platform for GPCR Ligands.ACS chemical biology · 2026Article
- Dorsal striatal circuit mechanisms contributing to astrocyte modulation of alcohol-related behaviors.bioRxiv : the preprint server for biology · 2026Article
- Neuromodulator Dynamics Underlying Associative Learning in the Ventral Striatum's Olfactory Tubercle.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Spatiotemporally dynamic noradrenergic regulation of cortical networks.bioRxiv : the preprint server for biology · 2026Article
- Inferring norepinephrine dynamics from partial observations reveals the temporal structure of elevations during arousal.bioRxiv : the preprint server for biology · 2026Article
- Visual attention is linked to temporally structured noradrenaline release in the medial prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Astrocytes Control Norepinephrine Signaling in the Brain.Neuroscience bulletin · 2026Article
- Next-generation multicolor indicators for in vivo imaging of norepinephrine.Nature methods · 2026Article
- Light-Based Molecular Tools to Precisely Monitor and Operate β-Adrenoceptors.Medicinal research reviews · 2026Review
- Multiparametric imaging of spatio-temporal cAMP signaling, transmembrane potential, and intracellular calcium in the intact heart.iScience · 2026Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 5 institutions in 2 countries.
Jiesi FengState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, New Cornerstone Science Laboratory, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China. Electronic address: jiesifeng@pku.edu.cn.
Hui DongState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, New Cornerstone Science Laboratory, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
Julieta E LischinskyNeuroscience Institute, New York University School of Medicine, New York, NY 10016, USA.
Jingheng ZhouNeurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Fei DengState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China.
Chaowei ZhuangDepartment of Automation, Tsinghua University, Beijing 100084, China.
Xiaolei MiaoState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China; Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, 100020 Beijing, China.
Huan WangState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China.
Guochuan LiState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.
Ruyi CaiState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.
Hao XieDepartment of Automation, Tsinghua University, Beijing 100084, China.
Guohong CuiNeurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Dayu LinNeuroscience Institute, New York University School of Medicine, New York, NY 10016, USA.
Yulong LiState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, New Cornerstone Science Laboratory, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; Chinese Institute for Brain Research, Beijing 102206, China; Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518055, China; National Biomedical Imaging Center, Peking University, Beijing 100871, China. Electronic address: yulongli@pku.edu.cn.
Peking University · CNNational Institutes of Health · USNew York University · USTsinghua University · CNCapital Medical University · CN
Funding
Basal Ganglia in Health and DiseaseZIAES103310 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CUI, GUOHONG · 2016 to 2025
$23.6MNovel fluorescent sensors for imaging neuromodulationU01NS113358 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI DAN, YANG, LI, YULONG · 2019 to 2022
$4.3MOptimization of GPCR-based fluorescent sensors for large-scale multiplexed in vivo imaging of neuromodulationU01NS120824 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIRES, SAMUEL ANDREW, LI, YULONG · 2021 to 2024
$3.6MNovel fluorescent sensors based on GPCRs for imaging neuromodulationU01NS103558 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIRES, SAMUEL ANDREW, LI, YULONG · 2017 to 2019
$2.2MDevelopmental and circuit mechanisms for innate social behaviors in the medial amygdalaK99MH127295 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LISCHINSKY, JULIETA E · 2021 to 2022
$261kIntramural NIH HHS ZIA ES103310NIMH NIH HHS K99 MH127295NINDS NIH HHS U01 NS103558NINDS NIH HHS U01 NS113358NINDS NIH HHS U01 NS120824
Abstract
Norepinephrine (NE) is an essential biogenic monoamine neurotransmitter. The first-generation NE sensor makes in vivo, real-time, cell-type-specific and region-specific NE detection possible, but its low NE sensitivity limits its utility. Here, we developed the second-generation GPCR-activation-based NE sensors (GRAB
Indexed as
Locus CoeruleusMice, TransgenicNorepinephrineOptogeneticsAnimalsBiosensing TechniquesCalciumHEK293 CellsHumansHypothalamusMaleMiceMice, Inbred C57BLPhotometryReceptors, G-Protein-CoupledSleepCalciumNorepinephrineReceptors, G-Protein-Coupleddual-color imagingfluorescent sensorsGRABin vivo imagingmesoscopic imagingneuromodulationnorepinephrinetransgenic mouse line
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.