Evidence map›Paper›PMID 38547719›Full record

ArticleSchizophrenia research2024

Inpatient antipsychotic medication switching and rehospitalization risk among patients with schizophrenia-spectrum disorders.

Y Nina Gao, Rui Wang, Gyojeong Gu, Rakkoo Chung, Mark Olfson

Abstract read
In one paragraph

Article in Schizophrenia research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Y Nina GaoDepartment of Psychiatry, Vagelos College of Physicians & Surgeons Columbia University and New York State Psychiatric Institute, New York, United States of America. Electronic address: yihe.gao@nyspi.columbia.edu.
Rui WangNew York State Office of Mental Health, Albany, New York, United States of America.
Gyojeong GuNew York State Office of Mental Health, Albany, New York, United States of America.
Rakkoo ChungNew York State Office of Mental Health, Albany, New York, United States of America.
Mark OlfsonDepartments of Psychiatry and Epidemiology, Columbia University, New York and New York State Psychiatric Institute, New York, United States of America.

Funding

Research Training in Mood and Anxiety Disorders: From Animal Models to PatientsT32MH015144 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Eduardo David Leonardo · 1985 to 2026
$11.1M
PRIMING THE PUMP: TRAINING PHYSICIAN-SCIENTISTS IN TRANSLATIONAL PSYCHIATRYR25MH086466 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Melissa Arbuckle, Eduardo David Leonardo · 2009 to 2026
$4.3M
NIMH NIH HHS R25 MH086466NIMH NIH HHS T32 MH015144
6 · The paper itself

Abstract

objectiveTo describe patterns of antipsychotic switching among patients hospitalized for schizophrenia and to correlate antipsychotic switching with hospital readmission risk.

methodsWe identified 3295 patients with index hospitalizations for schizophrenia or schizoaffective disorder from New York State Medicaid claims 2017-2018 who had filled at least one prescription for an antipsychotic in both the 44 days (one month +14 day grace period) prior to and after their admission. We identified patients who had kept or switched any of their antipsychotic medication between the pre- and post-periods surrounding their index hospitalization. We compared the kept and switched any groups, adjusting for patient characteristics.

resultsOf patients who had filled antipsychotic prescriptions in both the 44 days prior to and after their hospitalization, 1599 (48.6 %) had switched at least one antipsychotic and 1215 (36.8 %) had switched their primary antipsychotic. Switching any antipsychotic was associated with increased hazards of readmission, HR = 1.21, 95%CI 1.09-1.35, which was slightly concentrated during the first 90 days after hospital discharge.

conclusionsSwitching antipsychotic medications during hospitalization occurs commonly and is associated with higher rehospitalization risk following hospital discharge.

Indexed as

Antipsychotic AgentsDrug SubstitutionPatient ReadmissionPsychotic DisordersSchizophreniaAdultFemaleHospitalizationHumansInpatientsMaleMedicaidMiddle AgedNew YorkUnited StatesYoung AdultAntipsychotic AgentsAntipsychoticsSchizophreniaSwitching

Identifiers

PMID38547719
PMCPMC11102831

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.