Evidence map›Paper›PMID 38547689›Full record

ArticleThrombosis research2024

Syk inhibition suppresses NLRP3 inflammasome activation in platelets from sickle cell mice leading to decreased platelet secretion, aggregation, spreading, and in vitro thrombus formation.

Sebastian Vogel, Sayuri Kamimura, Meghann L Smith, Luis E F Almeida, Xizhong Cui, Christian A Combs, Zenaide M N Quezado

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Thrombosis research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sebastian VogelDepartment of Perioperative Medicine, National Institutes of Health Clinical Center, USA.
Sayuri KamimuraDepartment of Perioperative Medicine, National Institutes of Health Clinical Center, USA.
Meghann L SmithDepartment of Perioperative Medicine, National Institutes of Health Clinical Center, USA.
Luis E F AlmeidaDepartment of Perioperative Medicine, National Institutes of Health Clinical Center, USA.
Xizhong CuiCritical Care Medicine Department, National Institutes of Health Clinical Center, USA.
Christian A CombsLight Microscopy Core, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Zenaide M N QuezadoDepartment of Perioperative Medicine, National Institutes of Health Clinical Center, USA. Electronic address: zquezado@cc.nih.gov.

Funding

Neurobiology of pain and behavior changes associated with rare diseases and developmental disabilitiesZIACL090052 · CLC · CLINICAL CENTER · PI QUEZADO, ZENAIDE · 2017 to 2025
$0k
Pathobiology of pain in sickle cell diseaseZIACL090053 · CLC · CLINICAL CENTER · PI QUEZADO, ZENAIDE · 2017 to 2025
$0k
Development of novel strategies for the treatment of pain in childrenZIACL090054 · CLC · CLINICAL CENTER · PI QUEZADO, ZENAIDE · 2017 to 2025
$0k
Intramural NIH HHS ZIA CL090052Intramural NIH HHS ZIA CL090053Intramural NIH HHS ZIA CL090054
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anemia, Sickle CellInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinPlatelet AggregationSyk KinaseThrombosisAnimalsBlood PlateletsMiceInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseSyk KinaseFostamatinibNLRP3 inflammasomePlateletsSickle cell disease

Identifiers

PMID38547689
PMCPMC11614189

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.