Evidence map›Paper›PMID 38547555›Full record

ReviewCurrent opinion in structural biology2024

Structural biology in the age of X-ray free-electron lasers and exascale computing.

Sandra Mous, Frédéric Poitevin, Mark S Hunter, Dilipkumar N Asthagiri, Thomas L Beck

Abstract readReview
In one paragraph

Review in Current opinion in structural biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sandra MousLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, 94025, CA, USA.
Frédéric PoitevinLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, 94025, CA, USA.
Mark S HunterLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, 94025, CA, USA. Electronic address: mhunter2@slac.stanford.edu.
Dilipkumar N AsthagiriNational Center for Computational Sciences, Oak Ridge National Laboratory, Oak Ridge, 37830-6012, TN, USA.
Thomas L BeckNational Center for Computational Sciences, Oak Ridge National Laboratory, Oak Ridge, 37830-6012, TN, USA. Electronic address: becktl@ornl.gov.

Funding

Structural Dynamics at LCLSP41GM139687 · NIGMS · STANFORD UNIVERSITY · PI BOUTET, SEBASTIEN · 2021 to 2025
$7.5M
NIGMS NIH HHS P41 GM139687
6 · The paper itself

Abstract

Serial femtosecond X-ray crystallography has emerged as a powerful method for investigating biomolecular structure and dynamics. With the new generation of X-ray free-electron lasers, which generate ultrabright X-ray pulses at megahertz repetition rates, we can now rapidly probe ultrafast conformational changes and charge movement in biomolecules. Over the last year, another innovation has been the deployment of Frontier, the world's first exascale supercomputer. Synergizing extremely high repetition rate X-ray light sources and exascale computing has the potential to accelerate discovery in biomolecular sciences. Here we outline our perspective on each of these remarkable innovations individually, and the opportunities and challenges in yoking them within an integrated research infrastructure.

Indexed as

ElectronsLasersCrystallography, X-RayX-RaysBiomoleculesConformational dynamicsForcefieldsMetalloproteinsNucleic acids

Identifiers

PMID38547555
PMCPMC12854780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.