ArticleThe Journal of infectious diseases2024
Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study.
Open access · hybridAbstract readMulticenter Study
In one paragraph
Article in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
11.3field-weighted citation impact, top 1% of its field
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34 citing papers in PubMed, 28 citations in OpenAlex.
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- Prospective use of wastewater surveillance for early detection of enterovirus D68 in community outbreaks among children, Niigata City, Japan, 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026Article
- Circulation Patterns, Genetic Diversity, and Public Health Implications of Enterovirus D68, Europe, 2014-2024.Emerging infectious diseases · 2026Review
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- Clinical Insights and Severity of Enterovirus D68 Respiratory Infections in Vietnamese Children.Open forum infectious diseases · 2026Article
- Enterovirus respiratory infection in adults: an overlooked clinical burden emerging in the post-pandemic era.Le infezioni in medicina · 2026Article
- Respiratory enterovirus D68: virology, clinical surveillance, host-pathogen interactions, and therapeutic prospects.Frontiers in cellular and infection microbiology · 2026Review
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- Enterovirus-D68-Neglected Pathogen in Acute Respiratory Infections: Insights from Croatia.Pathogens (Basel, Switzerland) · 2026Article
- Circulated echovirus 18 strains in Guangdong Province and worldwide: A novel perspective on genetic diversity and recombination patterns.Virulence · 2025Article
- Subclade B3 and D3 enterovirus D68 among children with severe community-acquired pneumonia in China, 2021 to 2024.Scientific reports · 2025Article
- Sialic Acid-Containing Glycolipids Extend the Receptor Repertoire of Enterovirus-D68.ACS infectious diseases · 2025Article
- Global Prevalence of Non-Polio Enteroviruses Pre- and Post COVID-19 Pandemic.Microorganisms · 2025Review
- Epidemiological and Clinical Insights into Enterovirus Circulation in Europe, 2018-2023: A Multicenter Retrospective Surveillance Study.The Journal of infectious diseases · 2025Article
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Authors and funding
143 authors at 20 institutions in 22 countries.
Margarida Pires SimoesCentre for Infectious Disease Control, Dutch National Public Health Institute, Bilthoven, The Netherlands.ORCID 0000-0003-0997-5683
Emma B HodcroftGeneva Center of Emerging Viral Diseases, Geneva University Hospital and University of Geneva, Geneva, Switzerland.ORCID 0000-0002-0078-2212
Peter SimmondsNuffield Department for Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-7964-4700
Jan AlbertDepartment of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0001-9020-0521
Enagnon K AlidjinouLaboratoire de Virologie ULR, Univ Lille, Centre Hospitalier Universitaire de Lille, Lille, France.
Katia Ambert-BalayNational Reference Centre for Gastroenteritis Viruses, Laboratory of Virology-Serology, University Hospital of Dijon Bourgogne, Dijon, France.ORCID 0000-0002-2624-712X
Cristina AndrésRespiratory Viruses Unit, Microbiology Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Institut of Research, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.ORCID 0000-0002-3200-0895
Andrés AntónRespiratory Viruses Unit, Microbiology Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Institut of Research, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.ORCID 0000-0002-1476-0815
Christelle AuvrayNational Reference Centre for Gastroenteritis Viruses, Laboratory of Virology-Serology, University Hospital of Dijon Bourgogne, Dijon, France.ORCID 0000-0001-9782-170X
Jean-Luc BaillyLabaratoire Microorganismes: Génome Environnement-Epidemiology and Physiopathology of Enterovirus Diseases LMGE-EPIE Team, Université Clermont Auvergne, CNRS, Clermont-Ferrand, France.ORCID 0000-0002-9770-6450
Fausto BaldantiMicrobiology and Virology Department, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.ORCID 0000-0001-6559-8099
Capser BastingsLaboratory for Medical Microbiology, Eurofins-PAMM, Veldhoven, The Netherlands.
Stuart BeardEnteric Virus Unit, UK Health Security Agency, London, United Kingdom.
Carla BerenguaMicrobiology Department, Hospital Universitari de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Natasa BergincNational Laboratory of Health, Environment, and Food, Laboratory for Public Health Virology, Ljubljana, Slovenia.
Mandy BloemenClinical and Epidemiological Virology, Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium.
Soile BlomqvistDepartment of Health Security, Expert Microbiology Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Froukje BosmaLaboratory for Medical Microbiology and Public Health, Hengelo, The Netherlands.
Sindy BöttcherNational Reference Laboratory for Poliomyelitis and Enteroviruses, Robert Koch Institute, Berlin, Germany.ORCID 0000-0002-7521-093X
Laura BubbaEuropean Non-Polio Enterovirus Network.
Stafan BuderusGFO Kliniken Bonn, Betriebsstätte St Marien, Bonn, Germany.
Maria CabrerizoEnterovirus and Viral Gastroenteritis Lab, National Centre for Microbiology, Instituto de Salud Carlos III and the Spanish Research Networks Consortium of Epidemiology and Public Health, Madrid, Spain.
Cristina CalvoPediatric and Infectious Diseases Department, Hospital Universtiario La Paz, Fundación IdiPaz, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.ORCID 0000-0002-6503-3423
Cristina CelmaEnteric Virus Unit, UK Health Security Agency, London, United Kingdom.
Ferruccio CeriottiVirology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0002-0958-5354
Gemma ClarkClinical Microbiology, Nottingham University Hospitals National Health Service Trust, Nottingham, United Kingdom.ORCID 0000-0002-4471-4641
Inës CostaNational Reference Laboratory for Influenza and Other Respiratory Viruses, National Institute of Health Dr Ricardo Jorge, Lisbon, Portugal.ORCID 0000-0003-2430-0721
Marianne Coste-BurelVirology Department, Centre Hospitalier Universitaire Hôtel Dieu, University Hospital, Nantes, France.
Karen CouderéMicrovida, Laboratory of Medical Microbiology and Immunology, Elisabeth Tweesteden Hospital, Tilburg, The Netherlands.
Jeroen CremerCentre for Infectious Disease Control, Dutch National Public Health Institute, Bilthoven, The Netherlands.
Margarita Del Cuerpo CasasMicrobiology Department, Hospital Universitari de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Theo DaehneInstitute of Virology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Jessica de BeerLaboratory for Medical Microbiology and Public Health, Hengelo, The Netherlands.
Maria de Ceano-VivasPediatric and Infectious Diseases Department, Hospital Universtiario La Paz, Fundación IdiPaz, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.
Cillian De GascunNational Virus Reference Laboratory, University College Dublin, Dublin, Ireland.
Alexis de RougemontNational Reference Centre for Gastroenteritis Viruses, Laboratory of Virology-Serology, University Hospital of Dijon Bourgogne, Dijon, France.
Jonathan DeanNational Virus Reference Laboratory, University College Dublin, Dublin, Ireland.
Jennifer L DembinskiDepartment of Virology, Norwegian Institute of Public Health, Oslo, Norway.
Sabine DiedrichNational Reference Laboratory for Poliomyelitis and Enteroviruses, Robert Koch Institute, Berlin, Germany.
Javier Diez-DomingoCenter for Public Health Research (Foundation for the Promotion of Health and Biomedical Research in the Valencian Community), Generalitat Valenciana, Valencia, Spain, and the Spanish Research Networks Consortium of Epidemiology and Public Health, Instituto de Salud Carlos III, Madrid Spain.
Lena DillnerDepartment of Microbiology, Public Health Agency of Sweden, Solna, Sweden.
Dagny H DorenbergDepartment of Virology, Norwegian Institute of Public Health, Oslo, Norway.
Alexandra DucancelleLaboratoire de Virologie, Département de Biologie des Agents Infectieux, Centre Hospitalier Universitaire Angers, Angers, France.
Susanne DudmanDepartment of Microbiology, Oslo University Hospital, Oslo, Norway.
Robert DyrdakDepartment of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.
Anna-Maria Eis-HuebingerInsitute of Virology, Medical Faculty, University Bonn, Bonn, Germany.
Iker Falces-RomeroMicrobiology Department, Hospital Unviersitario La Paz, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.ORCID 0000-0001-5888-7706
Agnes FarkasNational Public Health Center, Budapest, Hungary.
Susan FeeneyRegional Virus Laboratory, Belfast Health and Social Care Trust, Royal Victoria Hospital, Belfast, United Kingdom.
Maria D Fernandez-GarciaEnterovirus and Viral Gastroenteritis Lab, National Centre for Microbiology, Instituto de Salud Carlos III and the Spanish Research Networks Consortium of Epidemiology and Public Health, Madrid, Spain.
Jacky FlipseLaboratory for Medical Microbiology and Immunology, Rijnstate, Velp, The Netherlands.
Kristina T FranckDanish World Health Organization National Reference Laboratory for Poliovirus, Statens Serum Institut, Copenhagen, Denmark.
Cristina GalliDepartment of Biomedical Sciences for Health, University of Milan, Milan, Italy.
Isabelle GarrigueVirology Department, University Hospital of Bordeaux, Bordeaux, France.
Felix GeeraedtsLaboratory for Medical Microbiology and Public Health, Hengelo, The Netherlands.
Irina GeorgievaNational Reference Laboratory for Enteroviruses, National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Federica GiardinaDepartment of Clinical Surgical Diagnostic and Pediatric Sciences, Università Degli Studi di Pavia, Pavia, Italy.
Raquel GuiomarNational Reference Laboratory for Influenza and Other Respiratory Viruses, National Institute of Health Dr Ricardo Jorge, Lisbon, Portugal.ORCID 0000-0002-4563-6315
Elenor HauzenbergerDepartment of Microbiology, Public Health Agency of Sweden, Solna, Sweden.
Esther HeikensDepartment of Medical Microbiology, St Jansdal Hospital, Harderwijk, The Netherlands.
Cécille HenquellLabaratoire Microorganismes: Génome Environnement-Epidemiology and Physiopathology of Enterovirus Diseases LMGE-EPIE Team, Université Clermont Auvergne, CNRS, Clermont-Ferrand, France.
Didier HoberLaboratoire de Virologie ULR, Univ Lille, Centre Hospitalier Universitaire de Lille, Lille, France.
Mario HönemannInstitute of Medical Microbiology and Virology, University of Leipzig, Leipzig, Germany.
Hannah Howson-WellsClinical Microbiology, Nottingham University Hospitals National Health Service Trust, Nottingham, United Kingdom.
Željka HruškarDepartment of Virology, Croatian Institute of Public Health, Zagreb, Croatia.
Niina IkonenDepartment of Health Security, Expert Microbiology Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Berthemarie ImbertVirology Department, Centre Hospitalier Universitaire Hôtel Dieu, University Hospital, Nantes, France.
Arjan R JanszLaboratory for Medical Microbiology, Eurofins-PAMM, Veldhoven, The Netherlands.
Marion JeannoëlNational Reference Center for Enteroviruses and Parechoviruses, Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France.
Helena JiřincováNational Reference Laboratory for Enteroviruses, National Institute of Public Health, Prague, Czech Republic.
Laurence JossetNational Reference Center for Enteroviruses and Parechoviruses, Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France.
Kathrin KeerenCommission for Polio Eradication in Germany, Robert Koch Institute, Berlin, Germany.
Naomie Kramer-LindhoutLaboratory Medical Microbiology and Immunology, Admiraal de Ruijter Hospital, Goes, The Netherlands.
Sidsel KrokstadDepartment of Medical Microbiology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Mouna LazrekLaboratoire de Virologie ULR, Univ Lille, Centre Hospitalier Universitaire de Lille, Lille, France.
Hélène Le Guillou-GuillemetteLaboratoire de Virologie, Département de Biologie des Agents Infectieux, Centre Hospitalier Universitaire Angers, Angers, France.
Caroline LefeuvreLaboratoire de Virologie, Département de Biologie des Agents Infectieux, Centre Hospitalier Universitaire Angers, Angers, France.
Andreas LindDepartment of Microbiology, Oslo University Hospital, Oslo, Norway.
Maja M LunarInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Melanie MaierInstitute of Medical Microbiology and Virology, University of Leipzig, Leipzig, Germany.
Stéphanie Marque-JuilletService de Biologie, Centre Hospitalier de Versailles Le Chesnay, France.
C Patrick McClureWolfson Centre for Global Virus Research, School of Life Sciences, University of Nottingham, Nottingham, United Kingdom.
James McKennaRegional Virus Laboratory, Belfast Health and Social Care Trust, Royal Victoria Hospital, Belfast, United Kingdom.
Adam MeijerCentre for Infectious Disease Control, Dutch National Public Health Institute, Bilthoven, The Netherlands.ORCID 0000-0001-8074-7582
Ana Menasalvas RuizPediatric Infectious Diseases Unit, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
Beatriz Mengual-ChuliáCenter for Public Health Research (Foundation for the Promotion of Health and Biomedical Research in the Valencian Community), Generalitat Valenciana, Valencia, Spain, and the Spanish Research Networks Consortium of Epidemiology and Public Health, Instituto de Salud Carlos III, Madrid Spain.
Sofie MidgleyDanish World Health Organization National Reference Laboratory for Poliovirus, Statens Serum Institut, Copenhagen, Denmark.
Audrey MirandLabaratoire Microorganismes: Génome Environnement-Epidemiology and Physiopathology of Enterovirus Diseases LMGE-EPIE Team, Université Clermont Auvergne, CNRS, Clermont-Ferrand, France.
Richard MolenkampDepartment of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.
Milagrosa MontesMicrobiology Department, Donostia University Hospital and Biogipuzkoa Health Research Institute, San Sebastián, Spain.
Antonio Moreno-DocónMicrobiology Department, Hospital Clínico Universitario Virgen de la Arrixaca, Instituto Murciano De Investigación Biosanitaria Arrixaca, Murcia University, Murcia, Spain.
Ursula MorleyNational Virus Reference Laboratory, University College Dublin, Dublin, Ireland.
Jean-Luc MurkMicrovida, Laboratory of Medical Microbiology and Immunology, Elisabeth Tweesteden Hospital, Tilburg, The Netherlands.
Ana Navascués-OrtegaMicrobiology Department, Complejo Hospitalario de Navarra, Navarra, Spain.
Roel NijhuisDepartment of Medical Microbiology and Immunology, Meander Medical Center, Amersfoort, The Netherlands.ORCID 0000-0003-4203-3858
Lubomira Nikolaeva-GlombNational Reference Laboratory for Enteroviruses, National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Svein A NordbøDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Sanela NumanovicDepartment of Virology, Norwegian Institute of Public Health, Oslo, Norway.
Massimo OggioniMicrobiology and Virology Unit, Department of Diagnostic Services, Azienda Socio Sanitaria Territoriale della Brianza, Vimercate, Italy.
Eider Oñate VergaraMicrobiology Department, Donostia University Hospital and Biogipuzkoa Health Research Institute, San Sebastián, Spain.
Jordi PacaudVirology Department, University Hospital of Bordeaux, Bordeaux, France.
Marie L PacreauService de Biologie, Centre Hospitalier de Versailles Le Chesnay, France.
Marcus PanningInstitute of Virology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Elena ParianiDepartment of Biomedical Sciences for Health, University of Milan, Milan, Italy.
Lili PekovaClinic of Infectious Diseases, University Hospital Prof Dr Stoyan Kirkovich AD, Stara Zagora, Bulgaria.
Laura PellegrinelliDepartment of Biomedical Sciences for Health, University of Milan, Milan, Italy.
Miroslav PetrovecInstitute of Microbiology and Immunology, Laboratory for the Diagnosis of Viral Infections, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Corinna PietschInstitute of Medical Microbiology and Virology, University of Leipzig, Leipzig, Germany.
Léa PilorgeUnité de Virologie, Département de Bactériologie-Virologie-Parasitologie-Mycologie-Hygiène, Pôle de Biologie-Pathologie, Centre Hospitalier Régional et Universitaire de Brest, Brest Cedex, France.
Luis PiñeiroMicrobiology Department, Donostia University Hospital and Biogipuzkoa Health Research Institute, San Sebastián, Spain.
Antonio PirallaMicrobiology and Virology Department, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.
Mario PoljakInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Birgit ProchazkaAustrian Agency for Health and Food Safety, National Reference Laboratory for Poliomyelitis, Vienna, Austria.
Nuria RabellaMicrobiology Department, Hospital Universitari de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Janette C Rahamat-LangendoenDepartment of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.
Petra RainetovaNational Reference Laboratory for Enteroviruses, National Institute of Public Health, Prague, Czech Republic.
Marijke ReyndersLaboratory Medicine, Molecular Microbiology, AZ St Jan Brugge-Oostende AV, Bruges, Belgium.
Annelies Riezebos-BrilmanLaboratory for Medical Microbiology and Public Health, Hengelo, The Netherlands.
Lieuwe RoordaDepartment of Medical Microbiology, Maasstad Hospital, Rotterdam, The Netherlands.
Carita Savolainen-KopraDepartment of Health Security, Expert Microbiology Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Isabelle SchuffeneckerNational Reference Center for Enteroviruses and Parechoviruses, Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France.
Leo C SmeetsDepartment of Medical Microbiology, Reinier Haga Medical Diagnostic Center, Delft, The Netherlands.
Asya StoyanovaNational Reference Laboratory for Enteroviruses, National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Karl SteficLaboratoire de Virologie INSERM U1259, Centre Hospitalier Régional, Universitaire de Tours, Tours, France.ORCID 0000-0002-9686-9194
Caroline SwaninkLaboratory for Medical Microbiology and Immunology, Rijnstate, Velp, The Netherlands.
Irena TabainDepartment of Virology, Croatian Institute of Public Health, Zagreb, Croatia.
Jeroen TjhieLaboratory for Medical Microbiology, Eurofins-PAMM, Veldhoven, The Netherlands.
Luc ThouaultUnité de Virologie, Département de Bactériologie-Virologie-Parasitologie-Mycologie-Hygiène, Pôle de Biologie-Pathologie, Centre Hospitalier Régional et Universitaire de Brest, Brest Cedex, France.
Camille TumiottoVirology Department, University Hospital of Bordeaux, Bordeaux, France.
Sara Uceda RenteriaVirology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0002-2027-8478
Tina UršičInstitute of Microbiology and Immunology, Laboratory for the Diagnosis of Viral Infections, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Sophie ValletUnité de Virologie, Département de Bactériologie-Virologie-Parasitologie-Mycologie-Hygiène, Pôle de Biologie-Pathologie, Centre Hospitalier Régional et Universitaire de Brest, Brest Cedex, France.
Marc Van RanstClinical and Epidemiological Virology, Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium.
Peter Van WunnikDepartment of Medical Microbiology, Reinier Haga Medical Diagnostic Center, Delft, The Netherlands.
Jaco J VerweijMicrovida, Laboratory of Medical Microbiology and Immunology, Elisabeth Tweesteden Hospital, Tilburg, The Netherlands.
Jorgina VilaPaediatric Hospital Medicine, Department of Paediatrics, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Bas WintermansLaboratory Medical Microbiology and Immunology, Admiraal de Ruijter Hospital, Goes, The Netherlands.
Elke WollantsClinical and Epidemiological Virology, Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium.
Katja C WolthersDepartment of Medical Microbiology, OrganoVIR Labs, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
F Xavier López-LabradorCenter for Public Health Research (Foundation for the Promotion of Health and Biomedical Research in the Valencian Community), Generalitat Valenciana, Valencia, Spain, and the Spanish Research Networks Consortium of Epidemiology and Public Health, Instituto de Salud Carlos III, Madrid Spain.ORCID 0000-0002-9403-8258
Thea Kolsen FischerDepartment of Clinical Research, Nordsjællands Hospital, Hilleroed, Denmark.ORCID 0000-0003-4812-980X
Heli HarvalaNuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, Oxford, United Kingdom.
Kimberley S M BenschopCentre for Infectious Disease Control, Dutch National Public Health Institute, Bilthoven, The Netherlands.ORCID 0000-0002-8328-0882
Instituto de Salud Carlos III · ESNational Institute for Public Health and the Environment · NLUniversity of Ljubljana · SIBiogipuzkoa Health Research Institute · ESCentre Hospitalier Régional Universitaire de Brest · FRCentre Hospitalier Universitaire d'Angers · FRCentre National de la Recherche Scientifique · FRElisabeth-TweeSteden Ziekenhuis · NLEurofins (Netherlands) · NLFinnish Institute for Health and Welfare · FIHospices Civils de Lyon · FRLeipzig University · DEMaison des Sciences sociales et des Humanités de Dijon · FRNational Center of Infectious and Parasitic Diseases · BGNational Health Service · GBNorwegian Institute of Public Health · NORega Institute for Medical Research · BERijnstate Hospital · NLRobert Koch Institute · DEUniversitat Autònoma de Barcelona · ES
Funding
Austrian Ministry of HealthCzechia Ministry of HealthEuropean Union PE00000007Foundation for Influenza Epidemiology PI18CIII-00035Ministry of HealthNational Health InsuranceNational Surveillance ProgramSanté Publique FranceSlovenian Research Agency P3-0083Swiss National Science Foundation 31CA30_196046UK Clinical Virology NetworkUniversity of BernWelfare and Sport, The Netherlands
Abstract
Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 infections and its clinical impact during the fall-winter season of 2021-2022. From 19 European countries, 58 institutes reported 10 481 (6.8%) EV-positive samples of which 1004 (9.6%) were identified as EV-D68 (including 852 respiratory samples). Clinical data were reported for 969 cases; 78.9% of infections were reported in children (0-5 years); and 37.9% of cases were hospitalized. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases including 6 diagnosed with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of 2 novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale European EV-D68 upsurge with severe clinical impact and the emergence of B3-derived lineages.
Indexed as
Enterovirus D, HumanEnterovirus InfectionsPhylogenyAdolescentAdultAgedCentral Nervous System Viral DiseasesChildChild, PreschoolEuropeFemaleHumansInfantInfant, NewbornMaleMiddle Agedacute flaccid myelitis (AFM)enterovirus D68 (EV-D68)European Non-Polio Enterovirus Network (ENPEN)nonpolio enterovirus (NPEV)respiratory infection
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