Evidence map›Paper›PMID 38547373›Full record

ReviewAmerican journal of respiratory cell and molecular biology2024

Application of Metabolomics across the Spectrum of Pulmonary and Critical Care Medicine.

Catherine E Simpson, Julie G Ledford, Gang Liu

Open access · greenAbstract readReview
In one paragraph

Review in American journal of respiratory cell and molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Early Sepsis Metabolic Changes in Kidney and Liver Precede Clinical Evidence of Organ Dysfunction.American journal of respiratory cell and molecular biology · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Catherine E SimpsonDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0002-2388-5660
Julie G LedfordDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona; and.
Gang LiuDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0003-2615-131X
Johns Hopkins University · USUniversity of Alabama at Birmingham · USUniversity of Arizona · US

Funding

Program on cellular metabolism and lung fibrosisR35HL135830 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LIU, GANG · 2017 to 2023
$5.2M
Defining mechanisms of CC16 on epithelial-driven host responses to pathogensR01HL142769 · NHLBI · UNIVERSITY OF ARIZONA · PI Julie Gunnells Ledford · 2019 to 2026
$4.2M
Mechanism and targeting of inflammasome activation in lung inflammation and injuryR01AI170913 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Gang Liu · 2023 to 2026
$2.3M
The role of xanthine oxidoreductase activity and altered metabolism in scleroderma-associated pulmonary arterial hypertensionK23HL153781 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SIMPSON, CATHERINE · 2020 to 2024
$883k
Determining the Role of Creatine Kinase in AsthmaR21AI178782 · NIAID · UNIVERSITY OF ARIZONA · PI LEDFORD, JULIE GUNNELLS · 2023 to 2024
$422k
National Institute of Allergy and Infectious Diseases AI178782National Institute of Allergy and Infectious Diseases R01AI170913NHLBI NIH HHS HL142769NHLBI NIH HHS K23 HL153781NHLBI NIH HHS K23HL153781NHLBI NIH HHS R01 HL142769NHLBI NIH HHS R35 HL135830NHLBI NIH HHS R35HL135830NIAID NIH HHS R01 AI170913NIAID NIH HHS R21 AI178782
6 · The paper itself

Abstract

In recent years, metabolomics, the systematic study of small-molecule metabolites in biological samples, has yielded fresh insights into the molecular determinants of pulmonary diseases and critical illness. The purpose of this article is to orient the reader to this emerging field by discussing the fundamental tenets underlying metabolomics research, the tools and techniques that serve as foundational methodologies, and the various statistical approaches to analysis of metabolomics datasets. We present several examples of metabolomics applied to pulmonary and critical care medicine to illustrate the potential of this avenue of research to deepen our understanding of pathophysiology. We conclude by reviewing recent advances in the field and future research directions that stand to further the goal of personalizing medicine to improve patient care.

Indexed as

Critical CareMetabolomicsHumansLung DiseasesPrecision MedicinePulmonary Medicinemetabolomicspulmonary vascular disease

Identifiers

PMID38547373
PMCPMC11225873
OpenAlexW4393299629

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.