Evidence map›Paper›PMID 38547288›Full record

ArticleScience (New York, N.Y.)2024

Oxygen imaging of hypoxic pockets in the mouse cerebral cortex.

Felix R M Beinlich, Antonios Asiminas, Verena Untiet, Zuzanna Bojarowska, Virginia Plá, Björn Sigurdsson, Vincenzo Timmel, Lukas Gehrig, Michael H Graber, Hajime Hirase and 1 more

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 71 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Felix R M Beinlich *Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0002-6411-0909
Antonios Asiminas *Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0002-6492-0960
Verena UntietDivision of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0002-1888-6378
Zuzanna BojarowskaDivision of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0002-4485-9541
Virginia PláDivision of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0002-5501-0789
Björn SigurdssonDivision of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0002-7484-7779
Vincenzo TimmelSchool of Engineering, FHNW University of Applied Sciences and Arts Northwestern Switzerland, 5210 Windisch, Switzerland.ORCID 0009-0008-5435-2972
Lukas GehrigSchool of Engineering, FHNW University of Applied Sciences and Arts Northwestern Switzerland, 5210 Windisch, Switzerland.ORCID 0000-0002-8787-360X
Michael H GraberSchool of Engineering, FHNW University of Applied Sciences and Arts Northwestern Switzerland, 5210 Windisch, Switzerland.
Hajime HiraseDivision of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0003-3806-6905
Maiken NedergaardDivision of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0001-6502-6031
University of Copenhagen · DKFHNW University of Applied Sciences and Arts · CH

Funding

Viral Tool Development Core: Visualization and manipulation of brain fluid dynamics by recombinant viral vectorsU19NS128613 · NINDS · UNIVERSITY OF ROCHESTER · PI Laura Diane Lewis · 2022 to 2026
$13.6M
Lymphatic pacemaking and pumping in lymphedema: function, dysfunction, and rescueR01HL122578 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI DAVIS, MICHAEL JOHN · 2015 to 2023
$4.1M
The glymphatic system at the crossroad of integrative health approaches inchronic painR01AT011439 · NCCIH · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2021 to 2025
$3.1M
CRCNS: Waste-clearance flows in the brain measured using physics-informed neural networkR01AT012312 · NCCIH · UNIVERSITY OF ROCHESTER · PI Douglas H Kelley · 2022 to 2026
$1.6M
NCCIH NIH HHS R01 AT011439NCCIH NIH HHS R01 AT012312NHLBI NIH HHS R01 HL122578NINDS NIH HHS U19 NS128613
6 · The paper itself

Abstract

Consciousness is lost within seconds upon cessation of cerebral blood flow. The brain cannot store oxygen, and interruption of oxidative phosphorylation is fatal within minutes. Yet only rudimentary knowledge exists regarding cortical partial oxygen tension (

Indexed as

Cerebral CortexCerebrovascular CirculationHypoxia, BrainLuminescent MeasurementsOxygenOxygen SaturationAnimalsGreen Fluorescent ProteinsHypercapniaLuciferasesMicePartial PressureRecombinant Fusion ProteinsVasodilationGreen Fluorescent ProteinsLuciferasesnanolucOxygenRecombinant Fusion Proteins

Identifiers

PMID38547288
PMCPMC11251491
OpenAlexW4393279563

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.