ArticleCirculation research2024
Gut Microbiota and Blood Metabolites Related to Fiber Intake and Type 2 Diabetes.
Article in Circulation research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Plant-based diets and risk of type 2 diabetes: systematic review and dose-response meta-analysis.The British journal of nutrition · 2025Pooled it
- Association between improved erectile function and dietary patterns: a systematic review and meta-analysis.Asian journal of andrology · 2025Pooled it
- Effects of the MIND diet on cardiometabolic health and novel anthropometric measures in women with type 2 diabetes and insomnia: a randomized controlled trial.Nutrition journal · 2025Trial
- Global Metabolite Profiling in Feces, Serum, and Urine Yields Insights into Energy Balance Phenotypes Induced by Diet-Driven Microbiome Remodeling.The American journal of clinical nutrition · 2025Trial
- Selective Influence of Hemp Fiber Ingestion on Post-Exercise Gut Permeability: A Metabolomics-Based Analysis.Nutrients · 2025Trial
- GutiMeta · 2026Article
- Review
- Intake of Fiber From Different Food Sources and Type 2 Diabetes Risk: An Integrated Analysis of Epidemiological and Multiomic Data.Diabetes care · 2026Article
- Mass spectrometry-based metabolomics for studying gut microbiota-derived metabolites in biological samples.Journal of food and drug analysis · 2026Review
- Metabolomic Pathways Distinguishing Metabolically Healthy and Unhealthy Obesity from Normal-Weight: A Cross-Sectional Study.International journal of molecular sciences · 2026Article
- Phytosterols improve feed efficiency in yaks by enriching rumen Succiniclasticum.Animal microbiome · 2026Article
- Gut Microbiota and Metabolic Health: From Dysbiosis to Therapeutics.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026Review
- Specific gut microbes are associated with the incidence of cardiometabolic disease in the HELIUS cohort.NPJ biofilms and microbiomes · 2026Article
- Circulating gut microbial metabolites and risk of coronary heart disease: A prospective multi-stage metabolomics study.PLoS medicine · 2026Article
- Glutamine alleviates Staphylococcus aureus-induced mastitis by modulating macrophage polarisation.PLoS pathogens · 2026Article
- The HUNT study identifies host genetic factors reproducibly associated with human gut microbiota composition.Nature genetics · 2026Article
- Cross-Cultural Nutritional Epigenomics: Diet and Microbiome Interactions Shaping Type 2 Diabetes in Arab and Western Populations.Nutrients · 2026Review
- Dietary fiber enhances the intestinal profile of beneficial commensal Bacteroides acidifaciens and modulates bile acid metabolism in T2DM mice.Antonie van Leeuwenhoek · 2026Article
- Insights into the effects of gut microbiota and circulating metabolites on oral cancer: Mendelian randomization analysis and clinical validation.Frontiers in nutrition · 2026Article
- Association of gut microbiota and short-chain fatty acids with pre-diabetes and diabetes following gestational diabetes.Frontiers in microbiology · 2026Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundConsistent evidence suggests diabetes-protective effects of dietary fiber intake. However, the underlying mechanisms, particularly the role of gut microbiota and host circulating metabolites, are not fully understood. We aimed to investigate gut microbiota and circulating metabolites associated with dietary fiber intake and their relationships with type 2 diabetes (T2D).
methodsThis study included up to 11 394 participants from the HCHS/SOL (Hispanic Community Health Study/Study of Latinos). Diet was assessed with two 24-hour dietary recalls at baseline. We examined associations of dietary fiber intake with gut microbiome measured by shotgun metagenomics (350 species/85 genera and 1958 enzymes; n=2992 at visit 2), serum metabolome measured by untargeted metabolomics (624 metabolites; n=6198 at baseline), and associations between fiber-related gut bacteria and metabolites (n=804 at visit 2). We examined prospective associations of serum microbial-associated metabolites (n=3579 at baseline) with incident T2D over 6 years.
resultsWe identified multiple bacterial genera, species, and related enzymes associated with fiber intake. Several bacteria (eg,
conclusionsAmong United States Hispanics/Latinos, dietary fiber intake was associated with favorable profiles of gut microbiota and circulating metabolites for T2D. These findings advance our understanding of the role of gut microbiota and microbial metabolites in the relationship between diet and T2D.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.