Evidence map›Paper›PMID 38547060›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response.

Yahui Yan, Maithili Shetty, Heather P Harding, Ginto George, Alisa Zyryanova, Katherine Labbé, Amirhossein Mafi, Qi Hao, Carmela Sidrauski, David Ron

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Termination of the integrated stress response.Science (New York, N.Y.) · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Yahui YanCambridge Institute for Medical Research, Department of Clinical Biochemistry, University of Cambridge, Cambridge CB2 0XY, United Kingdom.ORCID 0000-0001-6934-9874
Maithili ShettyCambridge Institute for Medical Research, Department of Clinical Biochemistry, University of Cambridge, Cambridge CB2 0XY, United Kingdom.ORCID 0009-0009-8894-8552
Heather P HardingCambridge Institute for Medical Research, Department of Clinical Biochemistry, University of Cambridge, Cambridge CB2 0XY, United Kingdom.ORCID 0000-0002-7359-7974
Ginto GeorgeCambridge Institute for Medical Research, Department of Clinical Biochemistry, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
Alisa ZyryanovaCambridge Institute for Medical Research, Department of Clinical Biochemistry, University of Cambridge, Cambridge CB2 0XY, United Kingdom.ORCID 0000-0002-9885-6012
Katherine LabbéCalico Life Sciences, South San Francisco, CA 94080.
Amirhossein MafiCalico Life Sciences, South San Francisco, CA 94080.ORCID 0000-0002-8366-6785
Qi HaoCalico Life Sciences, South San Francisco, CA 94080.ORCID 0000-0001-6246-2153
Carmela SidrauskiCalico Life Sciences, South San Francisco, CA 94080.ORCID 0000-0002-4850-3112
David RonCambridge Institute for Medical Research, Department of Clinical Biochemistry, University of Cambridge, Cambridge CB2 0XY, United Kingdom.ORCID 0000-0002-3014-5636
University of Cambridge · GBEnzo Life Sciences (United States) · US

Funding

Wellcome Trust
6 · The paper itself

Abstract

Dephosphorylation of pSer51 of the α subunit of translation initiation factor 2 (eIF2α

Indexed as

Eukaryotic Initiation Factor-2Protein Processing, Post-TranslationalActinsAnimalsHumansPhosphorylationProtein Phosphatase 1ActinsEukaryotic Initiation Factor-2Protein Phosphatase 1eukaryotic initiation factor-2/*metabolismphosphorylationprotein crystallographyprotein phosphatase /*metabolismsubstrate specificity

Identifiers

PMID38547060
PMCPMC10998612
OpenAlexW4393278999

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.