Evidence map›Paper›PMID 38546951›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2024

Insights on the genomic diversity, virulence and resistance profile of a Campylobacter jejuni strain isolated from a hospitalized patient in Brazil.

Carolina Nogueira Gomes, Miliane Rodrigues Frazão, Amanda Aparecida Seribelli, Dillon Oliver Reese Barker, Emily Victoria Che, Mara Corrêa Lelles Nogueira, Eduardo Napoleon Taboada, Juliana Pfrimer Falcão

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PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Carolina Nogueira GomesDepartamento de Análises Clínicas, Toxicológicas E Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto- Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Miliane Rodrigues FrazãoDepartamento de Análises Clínicas, Toxicológicas E Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto- Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Amanda Aparecida SeribelliLaboratório de Patogenicidade Microbiana E Imunidade Inata, Faculdade de Medicina de Ribeirão Preto- Universidade de São Paulo, São Paulo, Brazil.
Dillon Oliver Reese BarkerNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Emily Victoria CheNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Mara Corrêa Lelles NogueiraCentro de Investigação de Microrganismos, Departamento de Doenças Dermatológicas, Infecciosas E Parasitárias- Faculdade de Medicina de São José Do Rio Preto, São José Do Rio Preto, São Paulo, Brazil.
Eduardo Napoleon TaboadaNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Juliana Pfrimer FalcãoDepartamento de Análises Clínicas, Toxicológicas E Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto- Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil. jufalcao@fcfrp.usp.br.ORCID http://orcid.org/0000-0002-1459-9355
Public Health Agency of Canada · CAUniversidade de São Paulo · BRFaculdade de Medicina de São José do Rio Preto · BRUniversidade de Ribeirão Preto · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 304399/2018-3Conselho Nacional de Desenvolvimento Científico e Tecnológico 304803/2021-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/23408-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/26043-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/19338-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/07013-0
6 · The paper itself

Abstract

Campylobacteriosis is currently recognized as one of the major causes of foodborne bacterial diseases worldwide. In Brazil, there is insufficient data to estimate the impact of Campylobacter in public health. The aim of this present study was to characterize a C. jejuni CJ-HBSJRP strain isolated from a hospitalized patient in Brazil by its ability to invade human Caco-2 epithelial cells, to survive in U937 human macrophages, and to assess its phenotypic antimicrobial resistance profile. In addition, prophages, virulence and antimicrobial resistance genes were search using whole-genome sequencing data. The genetic relatedness was evaluated by MLST and cgMLST analysis by comparison with 29 other C. jejuni genomes isolated from several countries. The CJ-HBSJRP strain showed an invasion percentage of 50% in Caco-2 polarized cells, 37.5% of survivability in U937 cells and was phenotypically resistant to ampicillin, ciprofloxacin and nalidixic acid. A total of 94 virulence genes related to adherence, biofilm, chemotaxis, immune modulation, invasion process, metabolism, motility and toxin were detected. The resistance genes bla

Indexed as

Anti-Bacterial AgentsCampylobacter InfectionsCampylobacter jejuniVirulence FactorsBrazilCaco-2 CellsDrug Resistance, BacterialGenetic VariationGenome, BacterialHumansMicrobial Sensitivity TestsMultilocus Sequence TypingVirulenceWhole Genome SequencingAnti-Bacterial AgentsVirulence FactorsAntimicrobial resistance profileCaco-2 and U-937 cell linesCampylobacter jejuniVirulenceWhole genome sequence

Identifiers

PMID38546951
PMCPMC11153483
OpenAlexW4393255099

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.