Evidence map›Paper›PMID 38546940›Full record

Trial reportJournal of nephrology2024

Effect of a single small volume fluid bolus with balanced or un-balanced fluids on chloride and acid-base status: a prospective randomized pilot study (the FLURES-trial).

M Raes, J A Kellum, R Colman, S Wallaert, M Crivits, F Viaene, M Hemeryck, D Benoit, J Poelaert, E Hoste

Open access · greenAbstract readRandomized Controlled TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in Journal of nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

M RaesDepartment of Intensive Care Medicine, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent University, Ghent, Belgium. matthias.raes@uzbrussel.be.ORCID 0000-0002-6809-6921
J A KellumDivision of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
R ColmanBiostatistics Unit, University of Ghent, Ghent, Belgium.
S WallaertBiostatistics Unit, University of Ghent, Ghent, Belgium.
M CrivitsDepartment of Intensive Care Medicine, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent University, Ghent, Belgium.
F ViaeneDepartment of Intensive Care Medicine, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent University, Ghent, Belgium.
M HemeryckDepartment of Intensive Care Medicine, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent University, Ghent, Belgium.
D BenoitDepartment of Intensive Care Medicine, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent University, Ghent, Belgium.
J PoelaertDepartment of Intensive Care, Brussels University Hospital, Brussels, Belgium.
E HosteDepartment of Intensive Care Medicine, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent University, Ghent, Belgium.
Ghent University Hospital · BEGhent University · BEAntwerp University Hospital · BEQueen Elisabeth Medical Foundation · BEUniversity of Pittsburgh Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the short-term effects on acid base, electrolyte status and urine output of a single fluid bolus of saline to that of the balanced solution Plasmalyte

methodsProspective, randomized, controlled trial. Adult patients (≥ 18 years) admitted to the ICU receiving a fluid bolus were randomized to receive 1 L of saline (NaCl 0.9%, Baxter) or a balanced fluid [Plasmalyte MAIN

resultsPatients who received a 1 L saline fluid bolus had a significant increase in serum chloride (1.60; 95% CI 1.10 to 2.10; P < 0.001) and short-term decrease in apparent strong ion difference (- 1.85; 95% CI - 2.71 to - 0.99; P < 0.001) and base excess (- 0.90; 95% CI - 1.31 to - 0.50; P < 0.001). We observed a 17% increase in patients developing hyperchloremia in the saline group (0.17; 95% CI 0.05 to 0.29; P = 0.005). No significant difference in urinary output, blood pressure or vasopressor need was observed in either group.

conclusionEven a single, small bolus of saline, administered to critically ill patients, causes a significant increase in chloride concentration and a decrease in apparent strong ion difference and base excess, and an increase in the number of patients developing hyperchloremia. No difference in effect on urinary output, blood pressure or vasopressor need was observed between the two groups. EUDRACT NUMBER: 2014-001005-41; date of registration: 28/10/2014. LOCAL EC APPROVAL: EC project number 2014/038.

Indexed as

Acid-Base EquilibriumChloridesCritical IllnessFluid TherapySaline SolutionAdultAgedBlood PressureElectrolytesFemaleHumansMagnesium ChlorideMaleMiddle AgedPilot ProjectsPlasma SubstitutesChloridesElectrolytesMagnesium ChloridePlasmalyte APlasma SubstitutesPotassium ChlorideSaline SolutionSodium ChlorideVasoconstrictor AgentsAKIBalanced solutionsHyperchloremiaHyperchloremic metabolic acidosisMortalitySaline

Identifiers

PMID38546940
OpenAlexW4393277715

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.