ArticleeLife2024
Neurophysiological trajectories in Alzheimer's disease progression.
Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Tracking electrophysiological signatures of Alzheimer's disease: a systematic review of multimodal studies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Magnetoencephalography in human neuroscience research: planning, piloting, implementation and quality assurance.Nature protocols · 2026Review
- A multi-frequency whole-brain neural mass model with homeostatic feedback inhibition.PLoS computational biology · 2026Article
- Abnormal hippocampo-cortical theta-gamma phase-amplitude coupling in Alzheimer's disease.medRxiv : the preprint server for health sciences · 2026Article
- Multi-dimensional EEG analysis reveals distinct neurophysiological patterns in Alzheimer's and frontotemporal dementia.Journal of neuroengineering and rehabilitation · 2026Article
- Behavioral, Histopathological, and Biochemical Implications of Aloe Emodin in Copper-Aβ-Induced Alzheimer's Disease-like Model Rats.Current issues in molecular biology · 2026Article
- Potential Risk to Brain Health after Surgical Interventions: Biomarkers to Predict the Occurrence of Cognitive Decline.Aging and disease · 2025Review
- Benchmarking the utility of dry-electrode electroencephalography for clinical trials.Scientific reports · 2025Article
- A multi-frequency whole-brain neural mass model with homeostatic feedback inhibition.bioRxiv : the preprint server for biology · 2025Article
- Back to the Future: Predicting Individual Tau Progression in Alzheimer's Disease.Research square · 2025Article
- Personalized brain models link cognitive decline progression to underlying synaptic and connectivity degeneration.Alzheimer's research & therapy · 2025Article
- Exploring the neuromagnetic signatures of cognitive decline from mild cognitive impairment to Alzheimer's disease dementia.EBioMedicine · 2025Article
- GREEN: A lightweight architecture using learnable wavelets and Riemannian geometry for biomarker exploration with EEG signals.Patterns (New York, N.Y.) · 2025Article
- Effects of Alzheimer's disease plasma marker levels on multilayer centrality in healthy individuals.Alzheimer's research & therapy · 2025Article
- Neurophysiological signatures of ageing: compensatory and compromised neural mechanisms.Brain communications · 2025Article
- Exercise mitigates Alzheimer's disease by targeting ferroptosis driven by cellular senescence.Frontiers in cell and developmental biology · 2025Review
- Minimum spanning tree analysis of unimpaired individuals at risk of Alzheimer's disease.Brain communications · 2024Article
- Functional network disruption in cognitively unimpaired autosomal dominant Alzheimer's disease: a magnetoencephalography study.Brain communications · 2024Article
- Network Hyperexcitability in Early-Stage Alzheimer's Disease: Evaluation of Functional Connectivity Biomarkers in a Computational Disease Model.Journal of Alzheimer's disease : JAD · 2024Article
- Clinically altered brain activity may not look like aged brain activity: Implications for brain-age modeling and biomarker strategies.Alzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β and misfolded tau proteins causing synaptic dysfunction, and progressive neurodegeneration and cognitive decline. Altered neural oscillations have been consistently demonstrated in AD. However, the trajectories of abnormal neural oscillations in AD progression and their relationship to neurodegeneration and cognitive decline are unknown. Here, we deployed robust event-based sequencing models (EBMs) to investigate the trajectories of long-range and local neural synchrony across AD stages, estimated from resting-state magnetoencephalography. The increases in neural synchrony in the delta-theta band and the decreases in the alpha and beta bands showed progressive changes throughout the stages of the EBM. Decreases in alpha and beta band synchrony preceded both neurodegeneration and cognitive decline, indicating that frequency-specific neuronal synchrony abnormalities are early manifestations of AD pathophysiology. The long-range synchrony effects were greater than the local synchrony, indicating a greater sensitivity of connectivity metrics involving multiple regions of the brain. These results demonstrate the evolution of functional neuronal deficits along the sequence of AD progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.