Evidence map›Paper›PMID 38546211›Full record

ArticleJournal of virology2024

Exploring the therapeutic potential of DV-B-120 as an inhibitor of dengue virus infection.

Yi-Jung Huang, Tian-Lu Cheng, Yen-Tseng Wang, Chien-Shu Chen, Yu-Ling Leu, Chih-Shiang Chang, Cheng-Han Ho, Shi-Wei Chao, Chia-Tse Li, Chih-Hung Chuang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yi-Jung HuangDepartment of Biochemistry, School of Post Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID 0000-0002-2074-4096
Tian-Lu ChengDepartment of Biochemistry, School of Post Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Yen-Tseng WangDepartment of Biochemistry, School of Post Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chien-Shu ChenDrug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.
Yu-Ling LeuDepartment of Pharmacy, Chia Nan University of Pharmacy & Science, Tainan, Taiwan.
Chih-Shiang ChangSchool of Pharmacy, China Medical University, Taichung, Taiwan.
Cheng-Han HoDepartment of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan.
Shi-Wei ChaoDepartment of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chia-Tse LiDepartment of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chih-Hung ChuangDrug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID 0000-0002-1221-6584
Kaohsiung Medical University · TWChia Nan University of Pharmacy and Science · TWChina Medical University · TW

Funding

Kaohsiung Medical University (KMU) KMU-DK(A)113017, PT111002 and KMU-DK(A)113017Ministry of Science and Technology, Taiwan MOST110-2320-B-037-027-MY3
6 · The paper itself

Abstract

Dengue fever, an infectious disease prevalent in subtropical and tropical regions, currently lacks effective small-molecule drugs as treatment. In this study, we used a fluorescence peptide cleavage assay to screen seven compounds to assess their inhibition of the dengue virus (DENV) NS2B-NS3 protease. DV-B-120 demonstrated superior inhibition of NS2B-NS3 protease activity and lower toxicity compared to ARDP0006. The selectivity index of DV-B-120 was higher than that of ARDP0006.

Indexed as

DengueDengue VirusPiperidinesAnimalsAntiviral AgentsCommunicable DiseasesEndopeptidasesMiceMice, Inbred ICRProtease InhibitorsViral Nonstructural Proteins1-methyl-4-(1-naphthylvinyl)piperidineAntiviral AgentsEndopeptidasesPiperidinesProtease InhibitorsViral Nonstructural Proteinscompetitive inhibitorDV-B-120NS2B-NS3 proteaseselectivity index

Identifiers

PMID38546211
PMCPMC11019862
OpenAlexW4393259677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.