Evidence map›Paper›PMID 38546116›Full record

ArticlePharmacology research & perspectives2024

Lanthanum hydroxide protects kidney through gut microbiota in a rat model of chronic kidney disease.

Yuan Gao, Shengnan Wang, Lijun Sun, Bing Li, Hong Liu, Ren Bu, Changhai Su, Min Guo, Yang Liu, Lulu Zhao and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology research & perspectives, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Yuan GaoInner Mongolia Medical University, Hohhot, China.
Shengnan WangChifeng College Affiliated Hospital, Chifeng, China.
Lijun SunInner Mongolia Medical University, Hohhot, China.
Bing LiInner Mongolia Medical University, Hohhot, China.
Hong LiuInner Mongolia Medical University, Hohhot, China.
Ren BuInner Mongolia Medical University, Hohhot, China.
Changhai SuOrdos Central Hospital, Ordos, China.
Min GuoOrdos Central Hospital, Ordos, China.
Yang LiuOrdos Central Hospital, Ordos, China.
Lulu ZhaoInner Mongolia Medical University, Hohhot, China.
Chao GuInner Mongolia Medical University, Hohhot, China.
Xiaojia LiInner Mongolia Medical University, Hohhot, China.
Xiaorong YuanInner Mongolia Medical University, Hohhot, China.
Qiwen WangInner Mongolia Medical University, Hohhot, China.
Gang LiInner Mongolia Medical University, Hohhot, China.ORCID https://orcid.org/0009-0005-4961-4980
Inner Mongolia Medical University · CNChifeng University · CN

Funding

Natural Science Foundation of Inner Mongolia Autonomous Region 2018MS08026Natural Science Foundation of Inner Mongolia Autonomous Region 2022JQ01
6 · The paper itself

Abstract

The progression of chronic kidney diseases (CKD) is complex, influenced by a myriad of factors including gut microbiota. While emerging evidence suggests that gut microbiota can have beneficial effects in managing CKD, it is also recognized that dysbiosis may contribute to the progression of CKD and associated uremic complications. Our previous research has demonstrated the efficacy of lanthanum hydroxide in delaying kidney failure and preserving renal function. However, the role of lanthanum hydroxide in modulating gut microbiota in this context remains unclear. In our study, we induced CKD in rats using adenine, leading to gut microbial dysbiosis, kidney pathology, and disturbances in amino acid metabolism. In this adenine-induced CKD model with hyperphosphatemia, treatment with lanthanum hydroxide improved renal function. This improvement was associated with the restoration of gut microbial balance and an increase in urine ammonium metabolism. These results suggest that the therapeutic potential of lanthanum hydroxide in CKD may be partly due to its ability to reshape gut microbiota composition. This study underscores the significance of lanthanum hydroxide in kidney protection, attributing its benefits to the modulation of gut microbiota in a rat model of CKD.

Indexed as

Gastrointestinal MicrobiomeLanthanumRenal Insufficiency, ChronicAdenineAnimalsDysbiosisKidneyRatsAdenineLanthanumlanthanum hydroxidechronic kidney diseasesgut microbiotalanthanum hydroxidemetabolomics

Identifiers

PMID38546116
PMCPMC10976425
OpenAlexW4393261363

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.