Evidence map›Paper›PMID 38546100›Full record

ArticleThe Journal of general virology2024

Acute Rift Valley fever virus infection induces inflammatory cytokines and cell death in

Kaleigh A Connors, Zachary D Frey, Matthew J Demers, Zachary P Wills, Amy L Hartman

Abstract read
In one paragraph

Article in The Journal of general virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kaleigh A ConnorsDepartment of Infectious Disease and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Zachary D FreyCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.
Matthew J DemersCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.
Zachary P WillsDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.
Amy L HartmanDepartment of Infectious Disease and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

Practices CoreUC7AI180311 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI William Paul Duprex · 2023 to 2026
$13.2M
Live-attenuated Rift Valley fever vaccines: comparative mechanisms of trans-placental transmission and vaccine efficacy for developing fetusesR01AI150792 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARTMAN, AMY L · 2020 to 2025
$3.7M
Mechanisms of Neuronal Infection by Prototype Emerging BunyavirusesR01AI178378 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Amy L Hartman · 2023 to 2026
$3.0M
Neuroprotective anti-inflammatory drugs as a novel combination therapy for neurological Rift Valley FeverR01NS101100 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARTMAN, AMY L · 2017 to 2021
$1.7M
Comparative Analysis of Bunyavirus NeuropathogenesisR56AI171920 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARTMAN, AMY L · 2022 to 2022
$1.1M
NIAID NIH HHS R01 AI150792NIAID NIH HHS R01 AI178378NIAID NIH HHS R56 AI171920NIAID NIH HHS UC7 AI180311NINDS NIH HHS R01 NS101100
6 · The paper itself

Abstract

Rift Valley fever virus (RVFV) is an emerging arboviral disease with pandemic potential. While infection is often self-limiting, a subset of individuals may develop late-onset encephalitis, accounting for up to 20 % of severe cases. Importantly, individuals displaying neurologic disease have up to a 53 % case fatality rate, yet the neuropathogenesis of RVFV infection remains understudied. In this study, we evaluated whether

Indexed as

Rift Valley FeverRift Valley fever virusAnimalsBrainCell DeathCytokinesRatsCytokinesbrain slice culturebunyavirusex vivo modelneurotropic virusRift Valley fever virusviral encephalitis

Identifiers

PMID38546100
PMCPMC10995633

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.