Evidence map›Paper›PMID 38546058›Full record

SynthesisAsian Pacific journal of cancer prevention : APJCP2024

Association of COX-2, TNF-α, TLR4, and IKKα With Survival of Patients With Oral Squamous Cell Carcinomas: A Systematic Review.

Fernando Figueiredo Biasin, Andre Medeiros Franco, Gabriel Campos Louzeiro, Karen Cherubini, Fernanda Goncalves Salum

Open access · goldAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Asian Pacific journal of cancer prevention : APJCP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Fernando Figueiredo BiasinSchool of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul-PUCRS, Porto Alegre, Brazil.
Andre Medeiros FrancoSchool of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul-PUCRS, Porto Alegre, Brazil.
Gabriel Campos LouzeiroSchool of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul-PUCRS, Porto Alegre, Brazil.
Karen CherubiniSchool of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul-PUCRS, Porto Alegre, Brazil.
Fernanda Goncalves SalumSchool of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul-PUCRS, Porto Alegre, Brazil.ORCID 0000-0001-7842-619X
Pontifícia Universidade Católica do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis review investigated the association of COX-2, TNF-α, TLR4, and IKKα with the survival of patients with oral squamous cell carcinoma (SCC).

methodsA systematic search was conducted in the databases PUBMED, Web of Science, LILACS, EMBASE, Scopus, and Cochrane Library. The studies should assess the expression of those proteins in the tumor and survival outcomes.

resultsTwenty-one articles were included. The meta-analysis results leaned towards an association of COX-2 overexpression with a lower overall survival. The estimated hazard ratio was 1.51 (95% CI 0.97, 2.33), but not statistically significant (p=0.07). A low heterogeneity was observed (I2=0%). Regarding TNF-α, TLR4, and IKKα, statistically significant results for the association with survival were presented, but there was not enough data to a meta-analysis.

conclusionCOX-2 overexpression may be associated with a poorer prognosis in oral SCC. The insufficiency of studies about TNF-α, TLR4, and IKKα restrained their validation as predictors of prognosis.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsMouth NeoplasmsCyclooxygenase 2HumansI-kappa B KinasePrognosisSquamous Cell Carcinoma of Head and NeckToll-Like Receptor 4Tumor Necrosis Factor-alphaCyclooxygenase 2I-kappa B KinaseTLR4 protein, humanToll-Like Receptor 4Tumor Necrosis Factor-alphaoral cancerTumor necrosis factor α , Cyclooxygenase 2, Kinase I𝜅B α Toll-like receptor 4

Identifiers

PMID38546058
PMCPMC11152409
OpenAlexW4393268021

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.