ArticleCancer medicine2024
Trauma plays an important role in acral melanoma: A retrospective study of 303 patients.
Article in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Comprehensive Genomic Profiling of Acral Melanoma: Insights From the AACR Project GENIE Database.The American Journal of dermatopathology · 2026Article
- Clinicopathological characteristics and prognosis of melanoma: A retrospective cohort study in Xinjiang, China.PloS one · 2026Article
- Seborrheic Keratosis-Like Melanoma: Novel Insights Into Clinical, Dermoscopic, and Reflectance Confocal Microscopy Diagnosis of an Atypical Melanoma Variant.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2025Article
- Poor prognosis of early-stage acral melanoma with a history of trauma: a multicenter analysis of 468 patients.The oncologist · 2025Article
- Association of Weight-Bearing Activity and Prognosis of Plantar Melanoma: An Unanticipated Perspective.Annals of surgical oncology · 2025Article
- Review
- Trauma plays an important role in acral melanoma: A retrospective study of 303 patients.Cancer medicine · 2024Article
- Unraveling the Obesity Paradox: Exploring the Impact of Body Weight on Cutaneous Melanoma Prognosis in Asian Population.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
introductionAcral melanoma (AM) is the most common subtype of malignant melanoma in China, with a very poor prognosis. Despite the frequent reporting of trauma events in AM cases, the precise etiology of AM remains elusive.
methodsA retrospective analysis was conducted on a cohort of 303 AM patients at Nanjing Drum Tower Hospital. The patients were categorized into four distinct groups based on different patterns of disease onset: trauma type (Type 1), pigmented nevus type (Type 2), pigmented nevi with trauma (Type 3), and pigmented nevi with natural ulceration (Type 4). Differences in clinicopathological features, genetic alterations, and tumor immune microenvironment (TIME) were analyzed.
resultsTraumatic events accounted for a large proportion of AM cases. Among these categories, Type 1 patients displayed the least favorable pathological traits and an immunosuppressive TIME. Common copy number variations (CNVs) were observed in CCND1, RB1, FGF19, and IL7R, while CNVs in CDK4 and TERT occurred less frequently in patients with a history of trauma (Type 1 and Type 3). Type 2 patients exhibited the most favorable pathological characteristics and genetic profiles, and demonstrated the lowest incidence of CCDN1 and RB1 CNVs but had the highest CDK4 CNVs. In contrast, the pathological behavior of Type 3 and Type 4 patients was in between Type 1 and Type 2. And patients in Type 3 and Type 4 displayed a more favorable overall microenvironment.
conclusionThis study provides a clinical classification of Chinese AM based on diverse clinical onset characteristics and highlights the important role of trauma in AM. These findings may help to guide the diagnosis, treatment, and prognosis of AM patients. Further investigations are imperative to elucidate the underlying mechanisms governing the association between trauma and AM.
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