Evidence map›Paper›PMID 38545729›Full record

ArticleLa Tunisie medicale2024

Risk factors for treatment failure in multidrug resistant tuberculosis in Tunisia: An analytic study.

Fatma Tritar, Soumaya Ben Saad, Mariem Ferchichi, Amani Ben Mansour, Azza Slim, Othman Neffati, Hedia Bellili, Leila Slim, Hafaoua Daghfous

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in La Tunisie medicale, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Fatma TritarPulmonary department (C), Abderrahman Mami Hospital, Tunisia.
Soumaya Ben SaadPulmonary department (C), Abderrahman Mami Hospital, Tunisia.
Mariem FerchichiPulmonary department (C), Abderrahman Mami Hospital, Tunisia.
Amani Ben MansourPulmonary department (C), Abderrahman Mami Hospital, Tunisia.
Azza SlimPulmonary department (C), Abderrahman Mami Hospital, Tunisia.
Othman NeffatiPulmonary department, Menzel Bourguiba Hospital, Tunisia.
Hedia BelliliTunis El Manar University.
Leila SlimTunis El Manar University.
Hafaoua DaghfousPulmonary department (C), Abderrahman Mami Hospital, Tunisia.
Abderrahmane Mami Hospital · TNHabib hospital Thameur · TNHopital Universitaire Habib Bourguiba · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

INTRODUCTION-

aimThe emergence of multidrug resistant tuberculosis (MDR-TB) is a threat to global public health. The aim of our study was to determine risk factors for treatment failure in MDR-TB.

methodsRetrospective study conducted between January 2000 and March 2019 including patients with MDR-TB. Characteristics of patients with therapeutic failure were compared to cured ones. Logistic regression analysis was used to identify risk factors for treatment failure.

resultsOur study included 140 patients aged of 42±13 years (18-80). Fifty-seven percent of patients had treatment success and 12% had treatment failure. In multivariate logistic regression analysis, treatment failure was associated with age over 45 years (OR=1.05; 95%CI, 1.024-7.736;p=0.014), primary education level and illiteracy (OR=5.022; 95%CI, 1.316-19.161;p=0,018), history of incarceration (OR=3.291; 95%CI, 1.291-21.083;p=0.016), undernutrition (OR=4.544; 95%CI, 2.304-54.231;p=0,027), extensive TB (OR=6.406; 95%CI, 1.761-23.922; p=0.038), initial high grade positive smears (OR=1.210; 95%CI, 1.187-32.657; p=0.045), positive smear culture at 90 days of treatment (OR=6.871, 95%CI, 3.824-23.541; p=0.003), poor adherence (OR=6.110; 95%CI, 2.740-12.450; p=0.021) and occurrence of psychiatric adverse events (OR=3.644 95%CI, 2.560- 27.268; p=0.041).

conclusionTherapeutic education, nutritional and psychological support and close follow-up are strongly recommended to optimize the prognosis of MDR-TB.

Indexed as

Mycobacterium tuberculosisTuberculosis, Multidrug-ResistantAgedAntitubercular AgentsHumansMiddle AgedRetrospective StudiesRisk FactorsTreatment FailureTunisiaAntitubercular Agentsepidemiologymycobacterium tuberculosisNorth AfricaPrognosissecond-line drugsusceptibility testTunisia

Identifiers

PMID38545729
PMCPMC11261501
OpenAlexW4392390438

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.