ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Sex-specific blood biomarkers linked to memory changes in middle-aged adults: The Framingham Heart Study.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Identifying proteomic prognostic markers for Alzheimer's disease with survival machine learning: The Framingham Heart Study.The journal of prevention of Alzheimer's disease · 2025Article
- Identifying Proteomic Prognostic Markers for Alzheimer's Disease with Survival Machine Learning: the Framingham Heart Study.medRxiv : the preprint server for health sciences · 2024Article
- Sex-specific blood biomarkers linked to memory changes in middle-aged adults: The Framingham Heart Study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
8 authors at 2 institutions in 1 country.
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Abstract
The relationship between sex-specific blood biomarkers and memory changes in middle-aged adults remains unclear. We aimed to investigate this relationship using the data from the Framingham Heart Study (FHS). We conducted association analysis, partial correlation analysis, and causal dose-response curves using blood biomarkers and other data from 793 middle-aged participants (≤ 60 years) from the FHS Offspring Cohort. The results revealed associations of adiponectin and fasting blood glucose with midlife memory change, along with a U-shaped relationship of high-density lipoprotein cholesterol with memory change. No significant associations were found for the other blood biomarkers (e.g., amyloid beta protein 42) with memory change. To our knowledge, this is the first sex-specific network analysis of blood biomarkers related to midlife memory change in a prospective cohort study. Our findings highlight the importance of targeting cardiometabolic risks and the need to validate midlife-specific biomarkers that can accelerate the development of primary preventive strategies.
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