Evidence map›Paper›PMID 38545477›Full record

ReviewWorld journal of oncology2024

Pigs: Large Animal Preclinical Cancer Models.

Kirtan Joshi, Tejas Katam, Akshata Hegde, Jianlin Cheng, Randall S Prather, Kristin Whitworth, Kevin Wells, Jeffrey N Bryan, Timothy Hoffman, Bhanu P Telugu and 2 more

Abstract readReview
In one paragraph

Review in World journal of oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Baseline Characterization of Swine Leukocyte Antigen Diversity in GFP-Expressing Domestic Swine.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
    Article
  11. Review
  12. Review
  13. Review
  14. A TriAdj-AdjuvantedVaccines · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kirtan JoshiDivision of Hematology & Medical Oncology, Department of Medicine, University of Missouri, Columbia, MO, USA.
Tejas KatamRoy Blunt NextGen Precision Health Institute, University of Missouri, Columbia, MO, USA.
Akshata HegdeRoy Blunt NextGen Precision Health Institute, University of Missouri, Columbia, MO, USA.
Jianlin ChengRoy Blunt NextGen Precision Health Institute, University of Missouri, Columbia, MO, USA.
Randall S PratherNational Swine Resource and Research Center, Division of Animal Sciences, University of Missouri, Columbia, MO, USA.
Kristin WhitworthNational Swine Resource and Research Center, Division of Animal Sciences, University of Missouri, Columbia, MO, USA.
Kevin WellsNational Swine Resource and Research Center, Division of Animal Sciences, University of Missouri, Columbia, MO, USA.
Jeffrey N BryanDepartment of Veterinary Medicine and Surgery, University of Missouri, Columbia, MO, USA.
Timothy HoffmanDivision of Hematology & Medical Oncology, Department of Medicine, University of Missouri, Columbia, MO, USA.
Bhanu P TeluguNational Swine Resource and Research Center, Division of Animal Sciences, University of Missouri, Columbia, MO, USA.
Jussuf T KaifiSection for Thoracic Surgery, Department of Surgery, University of Missouri, Columbia, MO, USA.
Satyanarayana RachaganiRoy Blunt NextGen Precision Health Institute, University of Missouri, Columbia, MO, USA.

Funding

Targeting tumor and its microenvironment using nanotherapeutics for pancreatic cancerR01CA247763 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI RACHAGANI, SATYANARAYANA · 2020 to 2024
$1.9M
NCI NIH HHS R01 CA247763
6 · The paper itself

Abstract

Pigs are playing an increasingly vital role as translational biomedical models for studying human pathophysiology. The annotation of the pig genome was a huge step forward in translatability of pigs as a biomedical model for various human diseases. Similarities between humans and pigs in terms of anatomy, physiology, genetics, and immunology have allowed pigs to become a comprehensive preclinical model for human diseases. With a diverse range, from craniofacial and ophthalmology to reproduction, wound healing, musculoskeletal, and cancer, pigs have provided a seminal understanding of human pathophysiology. This review focuses on the current research using pigs as preclinical models for cancer research and highlights the strengths and opportunities for studying various human cancers.

Indexed as

Genetic engineeringOncopigsPigsPreclinical cancer modelSwineTranslational research

Identifiers

PMID38545477
PMCPMC10965265

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.