ArticleQuantitative imaging in medicine and surgery2024
Association between body mass index and glymphatic function using diffusion tensor image-along the perivascular space (DTI-ALPS) in patients with Parkinson's disease.
Article in Quantitative imaging in medicine and surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 17 citations in OpenAlex.
- Region-specific demographic determinants and hemispheric asymmetry of perivascular space burden in healthy adults: a quantitative 3T neuroimaging study.Neuroradiology · 2026Article
- Higher glymphatic system activity is linked to longer prodromal stage in isolated REM sleep behavior disorder: a possible protective factor.NPJ Parkinson's disease · 2026Article
- Longitudinal Neuroimaging Reveals Divergent Clinical Associations of Glymphatic Dysfunction and Dopaminergic Degeneration in Parkinson's Disease.Human brain mapping · 2026Article
- Metabolic inflammation at the adipose-brain axis.Frontiers in physiology · 2026Review
- Advances in MRI of glymphatic system dysfunction associated with obstructive sleep apnea and enlarged perivascular spaces.Frontiers in neurology · 2026Review
- Associations Between Obstructive Sleep Apnea, Macro-Scale Glymphatic Coupling, and Episodic Memory Impairment in Middle-Aged and Older Adults.Nature and science of sleep · 2026Article
- Impaired glymphatic system for upper limb motor dysfunction in patients with acute ischemic stroke.Quantitative imaging in medicine and surgery · 2025Article
- A systematic review and meta-analysis on glymphatic flow dysfunction in Parkinson's disease and Parkinsonism spectrum.NPJ Parkinson's disease · 2025Article
- The Glymphatic System and Obesity: A Diffusion Tensor Imaging ALPS Study.Biomedicines · 2025Article
- Impairment of the intracranial lymphatic system in Parkinson's disease: a combined study of the meningeal lymphatics vessels and glymphatic system based on noninvasive neuroimaging.European journal of medical research · 2025Article
- Diffusion tensor image analysis along the perivascular space index and visual analogue scales in female patients with patent foramen ovale and migraine perform better after percutaneous closure.Quantitative imaging in medicine and surgery · 2025Article
- Obstructive sleep apnea as a possible mediator for the association between glymphatic function and body mass index in Parkinson's disease.Quantitative imaging in medicine and surgery · 2025Article
- Glymphatic dysfunction evidenced by DTI-ALPS is related to obstructive sleep apnea intensity in newly diagnosed Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Widespread and prolonged pain may reduce brain clearance capacity only via sleep impairment: Evidence from participants with knee pain.The journal of pain · 2025Article
- Impaired glymphatic system in patent foramen ovale based on diffusion tensor imaging analysis along the perivascular space.Quantitative imaging in medicine and surgery · 2025Article
- Association of glymphatic system disturbance with neural dysfunction in amyotrophic lateral sclerosis.Quantitative imaging in medicine and surgery · 2025Article
- The glymphatic system as a nexus between obesity and neurological diseases.Nature reviews. Endocrinology · 2025Article
- Glymphatic system dysfunction in cerebral infarction: advances and perspectives based on DTI-derived ALPS measures.American journal of translational research · 2025Review
- Glymphatic system function in patients with ischemic stroke evaluated by the DTI-ALPS method: a comprehensive review.Frontiers in neurology · 2025Review
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6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Obesity is considered a risk factor for the development of several neurodegenerative diseases, including Parkinson's disease (PD). Recent studies have revealed that glymphatic function is compromised in PD patients. This study aims to investigate the impact of different body mass index (BMI) statuses on glymphatic system function in PD patients using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) method. Methods: This study used a cross-sectional study design. A total of 145 PD patients were retrospectively enrolled in Parkinson's Progression Markers Initiative (PPMI) from 2010-2013. Eligibility criteria included diagnosis of PD based on PPMI criteria. Diffusion tensor image (DTI) scans (diffusion gradient =64, b-value =1,000 s/mm Results: PD patients with higher BMI exhibited a reduced ALPS index (normal weight > overweight > obese), and the ALPS index for patients with obesity was statistically significantly lower than that for patients with normal weight (P<0.001). After adjusting for age, sex, years of education, handedness, and disease duration, a significant negative correlation between the ALPS index and BMI was observed in the PD patients (R=-0.275, P<0.001). Furthermore, a negative correlation between the ALPS index and the severity of motor symptoms was identified in the subgroup of overweight (R=-0.318, P=0.01), rather than in the normal weight and obese groups. Conclusions: High BMI has a negative impact on the glymphatic function in PD patients, suggesting that weight control may have clinical relevance in the management of PD patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.